肺鳞癌组织中Annexin-1 的表达及意义

doi:10.3971/j.issn.1000-8578.2011.01.011

肺鳞癌组织中Annexin-1 的表达及意义

Expression and Clinical Significance of Annexin-1 in Lung Squamous Carcinoma Tissues

摘要

摘要: 目的检测肺鳞癌组织中膜联蛋白Ⅰ(Annexin-1，Anx-A1)的表达水平，探讨其临床意义。方法采用实时荧光定量PCR(RQ-PCR)和Western blot方法检测22例肺鳞癌组织及其相应癌旁正常组织中Anx-A1 mRNA及蛋白的表达水平，并分析其与临床病理指标的关系。结果肺鳞癌组织中Anx-A1 mRNA和蛋白的表达水平均高于癌旁正常组织，在低分化肺鳞癌组织中的表达水平高于高、中分化肺鳞癌组织，差异具有统计学意义(P<0.05)。Anx-A1 在早期(Ⅰ期＋Ⅱ期)肺鳞癌组织和非早期(Ⅲ期)癌组织中表达水平的差异无统计学意义(P>0.05)。结论 Anx-A1在肺鳞癌中表达上调，可能与肺癌的发生、发展相关。

Abstract: Abstract:Objective To investigate the expression and significance of Annexin-1(Anx-A1) mRNA and protein in lung squamous carcinoma tissues. Methods Quantitative real-time PCR (qRT-PCR) and Western blot were used to detect Anx-A1 mRNA and protein levels in 22 cases of lung squamous carcinoma and corresponding adjacent normal tissues. The relationship between expressional levels and pathological characters was analyzed. Results The expression levels of Anx-A1 mRNA and protein in lung squamous carcinoma were significantly higher than those in adjacent normal tissues. The expression level of Anx-A1 in poor differentiated tissues was higher than that in middle and high differentiation tissues of lung squamous cell carcinoma(P<0.05). No expression difference between stage Ⅲ tumor tissues and stageⅠ~Ⅱ tissues was detected (P>0.05). Conclusion Up-regulated expressions of Anx-A1 mRNA and protein in lung squamous cell carcinoma tissue might contribute to lung carcinogenesis.

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