Abstract: Objective To study the technique of liposuction method to dissect axillary lymphy node in breast cancer. Methods Axillary lymph node dissection using liposuction was performed on 42 patients with breast cancer from June 2008 to Dec.2009.Thirty-four patients as a control were performed with traditions axillary lymph node dissection. Results There was no significant difference between 2 groups in intraoperative hemorrhage(P>0.05), and the total number of lymph nodes dissected and the number of positive lymph nodes dissected (P>0.05) and damaged lymph nodes.Liposuction can improve the rate of intercostobrachial nerve protection(P<0.05). No local recurrence and distant metastases cases were found in 2 groups during 6 months to 2 years follow-up. Conclusion Liposuction in modified radical operation of breast cancer was safe and feasible, as it was able to protect intercostobrachial nerve and provide the same operation scope and number of the lymph node dissection.