Abstract: Objective：To observe the characteristics of the pain of muscle and joint in patients with lung cancer during chemotherapy, define its potential inducers, explore its mechanism, and probe into the prevention and therapeutic ways. Methods：Ninety-three patients with lung cancer diagnosed by pathology or cytology were enrolled into study. Seventy-one cases were treated with double-drug chemotherapy regimen based on platinum，other 22 cases were treated with chemotherapy regimen without platinum. Stratification analysis was performed based on sex, age, type of pathology and chemotherapy regimen. Patients with muscle and joint pain were given calcium gluconate infusion. Results：Muscle and joint pain was found in 29 cases out of 71 cases treated with double-drug chemotherapy regimen including platinum agent while 22 cases treated with non-platinum regimen have no the similar symptoms. The incidence of muscle and joint pain was not correlated with gender, age and type of pathology. For chemotherapy regimen，the incidence was irrelative with which drugs platinum combined with, but there was significant difference between regimen including platinum agent and other regimens. The pain of muscle and joint was relieved in 29 cases after 6 days of intravenous infusion of calcium gluconate. Conclusion：Muscle and joint pain may be correlated with platinum agents. The mechanism of the relief of muscle and joint pain by calcium still keeps unclear. However, intravenous infusion of calcium gluconate has convincing effect on descending muscle and joint pain. This method can improve the life quality of patients.