Abstract: Objective：To evaluate the expression and clinical significance of CD44v6, survivin and β-Catenin in BAC. Methods：Clinic data of 74 inpatient cases from 1995-2002, were retrospectively reviewed. Expression of CD44v6, survivin and β-Catenin of surgically resected BAC specimens was studied by immunohistochemistry. The value of the three factors in identification of the prognosis of BAC was examined by survival analysis. Results ：The positive rate of CD44v6 and survivin were all significantly higher in stage Ⅲ and patients with lymphaden metastasis than that in stage Ⅰ~Ⅱ and without lymphaden metastasis (P<0.05). The positive rate of β-Catenin was significantly higher in low histological differentiation than that in high-middle histological differentiation (P<0.05). There was a statistically significant positive correlation between expression of CD44v6 and survivin (r=0.257, P<0.05). Strata analysis suggested that the survival time of BAC with CD44v6 positive was lower than that with CD44v6 negative in nonmucinous types, and the survival time of BAC with CD44v6 positive was lower than that with CD44v6 negative in stage Ⅲ (P<0.05). Cox Regression suggested that CD44v6,survivin, TNM stage, N stage and tumor diameter were independent factors affecting the prognosis of bronchioloalveolar carcinoma. Conclusion ：The expression of CD44v6,survivin and β-Catenin has a higher specificity, and there is a statistically significant positive correlation.Correlation between expression of CD44v6 and survivin. CD44v6 and survivin, TNM stage, tumor diameter and N stage are all independent factors affecting the prognosis of BAC.