Abstract: Objective To evaluate the effects of enteral nutrition on the treatment and immune function of grave reflux esophagitis patients. Methods Sixty-two patients were randomly divided into enteral nutrition (EN, n= 31) groups, and parenteral nutrition (PN, n=31) groups. Two study groups were treated with isocaloric and isonitrogonous nutrition to observe incidence rate of untoward reaction in treatment.Nutritional variables such as bodyweight, TSH, AMC,serum albumin,time from pretherapy to eating, subsets of lymphocytes (CD4, CD8, CD4/CD8) were measured on pretherapy and the 8th day after pretherapy. Results Untoward reaction occurs in two study groups, but the treatment could be finished. Nutritional variables were indifferent between pretherapy and the 8th day after pretherapy(P>0.05). Nutritional variables were no change between EN group and PN group(P>0.05). Time from pretherapy to eating in EN group were significantly lower than that in PN group (P<0.05). The percentage of CD4 and the number of CD4/CD8 in EN group were significantly higher than that in PN group (P<0.05). The percentage of CD4 and the number of CD4/CD8 in the 8th day after treatment were higher than that in pretherapy (P<0.05). CD8 were raised on two study groups, but there were no statistical differences between EN group and PN group. Conclusion EN as the treatment was safe,feasible and effective. EN compared with PN could effectively improve cell immunity of patient.