Abstract: Objective To evaluate the value for preoperative assessment of serum fibrinogen (FIB), inflammatory mediators（C-reactive protein, CRP; serum amyloid A protein, SAA）and tumor markers (CEA, CA19-9, CA72-4) in colorectal cancer. Methods One hundred and Seventy-eight patientswith colorectal cancer were recruited. The data were pooled to analyze the relationship　between the levels of serum FIB, CRP, SAA, CEA, CA19-9, CA72-4 measured preoperatively and compared with postoperativepathological stages postoperative. Results There were statistical differences of correlations between levels of FIB and CRP, SAA, CEA, CA19-9, of which the correlation coefficients were 0.600, 0.547, 0.168and0.231, respectively. The levels of FIB ( P =0.000), CRP( P =0.004), SAA( P =0.046), CEA( P =0.001), CA19-9( P =0.000) and CA72-4( P =0.040) were　significant difference in TNM stages. Contriving the ROC curve for metastatic colorectal cancer, the area under curve of FIB (A_Z=0.728), CRP(A_Z=0.646), SAA (A_Z=0.658), CA19-9 (A_Z=0.665)and CA72-4(A_Z=0.586) also hadstatistical significance, of which theP values were 0.000, 0.001, 0.042, 0.000and 0.049, respectively. While the critical point of FIB was defined as 3.715g/L, the accuracy, sensitivityand specificity ofthe prediction to metastatic colorectal cancer were 65.84%, 66.6%,66.3%,respectively. Conclusion Therelationships between FIB, inflammatory mediators and tumor markers were observed. Using FIB to evaluate colorectal patients with lymphatic metastasis preoperatively has potentially clinical value.