环氧合酶-2与HER-2、p53在膀胱移行细胞癌中的表达及其相关性

doi:10.3971/j.issn.1000-8578.2010.05.019

环氧合酶-2与HER-2、p53在膀胱移行细胞癌中的表达及其相关性

Expression of Cyclooxygenase-2 (COX-2)in Human Transitional Cell Carcinoma of Bladder and Its Relationship with HER-2 and p53

摘要

摘要: 目的探讨COX-2、HER-2和p53在膀胱移行细胞癌（BTCC）发生发展中其蛋白产物表达情况以及它们可能存在的相关性。方法采用免疫组织化学方法检测56例膀胱癌组织及10例正常膀胱组织中COX-2、HER-2和p53的表达情况。结果(1) 56例膀胱移行细胞癌组织中COX-2、HER-2和p53阳性表达率分别为57.1%（32/56）、51.8%（29/56）和50%（28/56），与正常膀胱黏膜组织中阳性表达率相比较，差异均有统计学意义(P <0.05)，COX-2、p53和HER-2蛋白在膀胱移行细胞癌中的阳性率在肿瘤病理分级和临床分期间差异有统计学意义( P <0.05)。(2)COX-2的表达与HER-2、p53的表达呈正相关性( P <0.05) 。结论 COX-2、p53和HER-2的异常表达可能在膀胱移行细胞癌的发生发展中起一定的作用，膀胱移行细胞癌COX-2表达可能和HER-2、p53的异常表达具有密切关联性。

Abstract: Objective To investigate the expression of COX-2, HER-2 and p53 in human transitional cell carcinoma of the bladder and their possible correlation. Methods SP immunohistochemistry staining was performed to evaluate the expression of COX-2, HER-2 and p53 in 56 cases of transitional cell carcinoma of the bladder and 10 cases of normal bladder mucosa. Results (1)The positive expression ratio of COX-2, HER-2 and p53 was 57.1%（32/56），51.8%（29/56）and 50%（28/56）, respectively. The difference between carcinoma group and normal tissues group was statistically significant ( P <0.05). The expression of all above genes was related to clinic stage and the tumor grade ( P <0.05). (2) The expression of HER-2 and p53wassignificant correlation with the expression of COX-2 ( P <0.05). Conclusion The abnormal expression of COX-2, HER-2 and p53 might play a certain role in course of the occurrence, development of transitional cell carcinoma of the bladder. The over-expression ofCOX-2 in transitional cell carcinoma of the bladder was correlated with the expression of HER-2 and p53.

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