Dickkopf-3在非小细胞肺癌组织中的表达及其临床意义

doi:10.3971/j.issn.1000-8578.2010.05.011

Dickkopf-3在非小细胞肺癌组织中的表达及其临床意义

Expression of Dickkopf-3 in Non-small Cell Lung Cancer and Its Significance

摘要

摘要: 目的：研究抑癌基因Dickkopf-3在非小细胞肺癌组织中的表达及其与肺癌临床指标间的关系，以探讨其在肺癌发生发展中的作用。方法：应用免疫组织化学技术检测Dkk-3蛋白在50例非小细胞肺癌和20例肺良性疾病组织中的表达，染色强度作半定量评分。结果：Dkk-3在非小细胞肺癌组织中阳性表达率为52%（26/50），而在肺良性疾病组织中阳性表达率为85%（17/20），并且Dkk-3在非小细胞肺癌组织中的表达水平显著低于肺良性疾病肺组织（ P <0.05）。Dkk-3在Ⅲ、Ⅳ期肺癌组织中的阳性表达率显著低于Ⅰ和Ⅱ期中的表达，并且染色强度也相应低于Ⅰ、Ⅱ期；已有淋巴结转移的肺癌组织中Dkk-3阳性表达率及染色强度均显著低于无淋巴结转移的肺癌组织（ P <0.05）；Dkk-3在不同性别以及肺鳞癌和腺癌组织中的表达无明显差异（ P >0.05）。结论：Dkk-3基因的低表达可能在非小细胞肺癌的发生发展中起一定作用，可能是一种潜在的肺癌抑癌基因。

Abstract: Objective：To investigate the correlation between the expression of Dickkopf-3 (Dkk-3) and the clinicopathologic features of non-small cell lung cancer (NSCLC). Methods：High sensitive SP immunohistochemical method was used to detect the expression ofDkk-3 in 50 NSCLC specimens and 20 benign lesion lung tissues. Results：Dkk-3 was expressed in 26 out of 50 human non-small cell lung cancer tissues, which was significantly lower than that in benign lesion tissues ( P <0.05). Furthermore, the decreased expression of Dkk-3 in lung cancer tissues was positive correlation with lymph migration and clinical stage, while no correlation was observed between the expression of Dkk-3 and sex or histological classification in non-small cell lung cancer. Conclusion：Dkk-3 gene may be a novel candidate of tumor-suppressor, and its inhibition may contribute to the progress of non-small cell lung cancer.

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