Abstract: Objective To study the inhibitory effect of Mesima Reishi UE-1 on growth and angiogenesis of Lewis pulmonary carcinoma. Methods The models of Lewis pulmonary carcinoma were used to test the effect of UE-1 on tumor growth, and microvessel density was investigated in entity tumor by immunohistochemical technique. The count of tumor-induced new vessel was used to manifest the effect of UE-1 on Lewis pulmonary carcinoma angiogenesis. The inhibition of UE-1 on chick chorioallantoic membrane (CAM) angiogenesis was studied by CAM assay. Results The average weight and volume of Lewis pulmonary carcinoma in UE-1 group were lower than those in control group(P<0.05). The MVD of entity tumor in UE-1 group was also lower than that in control group(P<0.05). The number of vesssels oriented toward the tumor mass in UE-1 group was less than that in control(P<0.05). The CAM assay showed that UE-1 polysaccharide had anti-angiogenic effect. Conclusion Mesima Reishi UE-1 can inhibit the growth of Lewis pulmonary carcinoma. The inhibitory mechanism may be related to anti-angiogenic activity of UE-1.