Abstract: Objective To study the relationship between the expression of P-glycoprotein (P-gp) and CD44v6 as well as their clinical significance in gastric carcinoma. Methods The expressions of P-gp and CD44v6 were detected by immunohistochemistry method in 97 patients with gastric carcinoma.Then their relationship with pathophysiologicalcharacteristics was evaluated.Meanwhile,the relationship between expression of P-glycoprotein (P-gp) and CD44v6 and the effect of them on clinical prognosis were also analyzed. Results The positive rate of P-gp and CD44v6 in 97 cases of gastric carcinoma were 40.21%and58.76%respectively.The expression of P-gp was associated with lymph node metastasis,vessel invasion and clinical stage; CD44v6 was associated with tumor size,lymph node metastasis,vessel invasion and clinical stage.There was a positive correlation between the expressions of P-gp and CD44v6.Moreover,survival rate of three years in both positive group was lower than that in both negative groups. Conclusion The expressions of P-gp and CD44v6 are not only associated with biologic behavior of gastric carcinoma,but also related to each other.Those who expressed both P-gp and CD44v6 have lower survival rate.Combined detecting of P-gp and CD44v6 may contribute to predicting the prognosis in gastric carcinoma.