Abstract: Objective To evaluate the efficacy of hepatic arterial infusion (HAI) chemotherapy combined with palliative gastrectomy for synchronous and multiple liver metastases from gastric cancer. Methods 29 patients with synchronous and multiple liver metastases from gastric cancer were divided into HAI group and non-HAI group. The efficacy of HAI chemotherapy group was retrospectively analyzed. Results In 14 patients from HAI group, 4 patients got CR and 7 patients got PR. The responding rate (CR+PR) of HAI chemotherapy was 78.6%. The median survival time was 13.7 months in HAI group and 9.4 months in non-HAI group with significant difference (log rank test, P＜0.05). Conclusion HAI chemotherapy is an effective treatment procedure for control of liver metastases which could be considered as an option for synchronous and multiple liver metastases from gastric cancer.