Abstract: Objective To study the expression of SDF-1 in different normal human tissues and its clinical significance; to indicate the expression of SDF-1 in normal hepatic tissue of colorectal carcinoma patients and its clinical significance. Methods Immunohistochemistry SP method was used to detect the expression of SDF-1 in three different kinds of human normal tissues of 30 cases, and the expression of SDF-1 and CXCR4 in 67 colorectal carcinoma tissue and their normal hepatic tissues tumor and 25 liver metastasitic tissue in colorectal carcinoma. The relationship between the expression of SDF-1 and metastasis of colorectal carcinoma was observed. Results The positive expression rates of SDF-1 was different in the skin tissue, the small intestinal mucosa and hepatic tissue, which was 20%，26.7% and 83.3% respectively; the positive expression rates of SDF-1 in the hepatic tissue was significantly higher than that in other tissues (P<0.05);the positive expression rates of SDF-1 in the normal liver tissue of colorectal carcinoma patients was 80.9% (54/67). The expression of SDF-1 in liver was correlated with the rate of liver metastatic in colorectal cancer. The higher expression of SDF-1, the more liver metastasis in colorectal cancer. Conclusion The hepatic tissue becomes metastatic aim of colorectal carcinoma because of its high expression of SDF-1. The high expressions of SDF-1/CXCR4 may play an important role in the process of colorectal carcinoma metastasis to liver.