Abstract: Objective 　To investigate the expression of Cyclooxygenase22 (COX22 ) and Angiopoietin22 (Ang22) in laryngeal carcinoma tissue and their correlation. Methods 　Sixty2five samples of laryngeal car2 cinoma and thirty2four biopsies of adjacent noncancerous tissue were immunohistochemically examined for expression of COX22 and Ang22, whose relationship with clinicopathological parameters was also ana2 lyzed. Results 　Percentages of COX22 and Ang22 expression in laryngeal carcinoma tissue were 63. 08 % and 69. 23 % respectively, which were higher than those in adjacent noncancerous tissue ( P < 0. 05) . The expression of COX22 and Ang22 significantly differed between patient s with different T stage and clinical stage, and there was also a close correlation between the expressions of COX22 and Ang22 ( P < 0. 05) . Kaplan2Meier analysis showed that disease2f ree survival and overall survival were significantly lower in patient s with COX22 positive expression than those with negative expression, but only overall survival was significantly lower in patient s with Ang22 overexpression ( P < 0. 05) . Conclusion 　The overexpres2 sion of COX22 and Ang22 was observed in laryngeal carcinoma tissue and there was positive correlation between them. It suggested that they may play an important role in the occurrence, infilt rating and diffu2 sion by promoting tumor angiogenesis. Their overexpression can be an objective indicator to judge biolog2 ical parameter and prognosis of laryngeal carcinoma.