EP、DP方案加同步放疗治疗局部晚期非小细胞肺癌观察

doi:10.3971/j.issn.1000-8578.1819

EP、DP方案加同步放疗治疗局部晚期非小细胞肺癌观察

Clinical Observation of EP,DP Regimen Combined with Radiotherapy in Treatment of Locally Advanced Non-small Cell Lung Cancer

摘要

摘要: 目的EP、DP方案加同步放疗治疗晚期非小细胞肺癌的疗效,毒副反应及耐受性观察。方法91例局部晚期非小细胞肺癌患者随机分为两组:EP方案加同步放疗46例,DP方案加同步放疗45例。放疗均采用钴60γ线常规分割照射。结果EP化放组、DP化放组有效率分别为52.2%、71.1%,但差异统计学意义(P>0.05)。两组完全缓解率分别为10.9%(5/46)、28.9%(13/45),两组比较差异有统计学意义。两组1、2年生存率分别为45.3%、62.4%和20.2%、32.6%。主要副反应为胃肠道反应、骨髓抑制、脱发,DP组较重,大部分病人可以耐受,无治疗相关性死亡。结论两方案同步放化疗治疗均可用于局部晚期非小细胞肺癌的一线综合治疗。

Abstract: Objective To observe the effect and the clinical toxicity between EP,DP regimen combined with concurrent radiotherapy in the treatment of locally advanced non-small cell lung cancer(NSCLC). MethodsNinety-one patients were randomly assigned into two groups .EP group:EP regimen concurrent radiotherapy for 46 cases, DP group: DP regimen concurrent radiotherapy for 45 cases, radiotherapy are conventional standard fractionation. Results The response rate in EP group and DP group were 52.2%,71.1% respectively(P>0. 05) . The local complete response rate were 10. 9 %(5/ 46), 28. 9 %(13/ 45) for the patient s t reated with EP, DP regimen respectively ( P < 0. 05) . One year survival rate in EP, DP group were 45. 3 %, 62. 4 % respectively. Two year survival rate wrer 20. 2 % and 32. 6 %. The major toxicity was gast rointestinal t ract reaction, myelosuppression and alopecia and so on. Most of patient s tolerate well . Conclusion 　EP, DP regimen concurrent radiotherapy has good clinical efficacy and safe in the combined therapy of locally advanced NSCLC. They could become the original regimen in locally advanced NSCLC.

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