胃癌中cyclinD_2和p27~(kipl)的表达及其意义

Significance of cyclinD_2 and p27~(kipl) Expressed in Gastric Carcinoma

摘要: 目的　探讨cyclinD2 、p2 7kipl的表达与胃癌发生发展的关系。方法　用免疫组化方法检测cy clinD2 和p2 7kipl在 12 0例胃癌、2 0例胃粘膜非典型增生、3 0例正常胃粘膜中的表达。结果　cyclinD2 在正常胃粘膜、非典型增生、胃癌中阳性表达率分别是 3 .3 %、10 %、和 3 4 .2 %, 胃癌与正常胃粘膜及非典型增生相比有显著性差异 (P <0 .0 1), p2 7kipl在正常胃粘膜、非典型增生、胃癌中表达分别是 10 0 %、90 %、和 52 .5%。胃癌与其他两组比较有显著性差异 (P <0 .0 1), p2 7kipl表达缺失和cyclinD2 胞浆阳性者与胃癌的分化程度、浸润深度、淋巴结转移有关 (P <0 .0 1)。cyclinD2 和p2 7kipl表达呈负相关。结论　cy clinD2 和 p2 7kipl与胃癌的发生有密切关系, p2 7kipl的表达缺失及cyclinD2 胞浆阳性者与胃癌的进展有关, p2 7kipl可作为估计预后的重要指标

Abstract: Objective To investigate the relationship between the expression of cyclinD 2 and p27 kipl in carcinogenesis and development of gastric carcinoma. Methods cyclinD 2 and p27 kipl were detected by S P immunohistochemical method in 120 cases of gastric carcinoma, 20 cases of dysplastic gastric mucosa and 30 cases of normal gastric mucosa. Results The positive expression rate of cyclinD 2 in cases with gastric carcinoma?dysplasia and normal gastric mucosa were 3.3%, 10% and ...