伽玛刀加体外照射治疗脑转移瘤疗效观察

An analysis of treatment result for brain metastasis of stereotactic radiosurgery plus radiotherapy

摘要: 目的　观察脑转移瘤采用伽玛刀加体外照射 (SRS +R)及单纯放疗 (R)的临床效果。方法　 1995年 5月～ 2 0 0 0年 12月, 38例脑转移瘤患者行SRS +R治疗, 中心剂量 5 0～ 6 0Gy, 周边剂量 2 0～ 2 5Gy, 全脑外照射 30～ 4 0Gy/ 3～ 4周。 4 6例R治疗, 全脑照射同前, 缩野追加至 4 0～ 6 0Gy。结果　中位生存期、1年生存率、肿瘤局部控制率, SRS +R组分别为 10月、6 0 .5 %及 92 .1% ;R组分别为 5 .3月、17.4 %及 2 1.7% (P <0 .0 1)。结论　SRS +R治疗脑转移瘤在延长患者生存期及肿瘤局部控制率明显优于R组。

Abstract: Objective To compare the effect in the treatment of brain metastasis between stereotatic radiosurgery puls radiotherapy (SRS+R) and radiotherapy (R) alone. Methods From May 1995 to December 2000, a total of 84 patients with brain metastasis were evaluated in this study . In SRS+R group, 38 patients were given SRS with the center dose of 50～60Gy and the bound dose of 20～25Gy, whole brain irradiation were given the dose of 30～40Gy in 3～4 weeks. In R group, 46 patients received a total dose of 40～60Gy with ...