Abstract: Objective 　To study the expression and interaction of Cyclooxygenase-2 (COX-2), basic fibroblast growth factor (BFGF), basic fibroblast growth factor receptor (BFGFR) in carcinoma of the colon and rectum and the relationship between both COX-2 and BFGF, BFGFR expression and Dukes stages and lymphnode metastasis. Methods 　49 intestinal biopsy specimens were taken from patient s with carcinoma of the colon and rectum and 20 hyperplastic polyp of intestine for cont rols, the expression of COX-2 and BFGF, BFGFR were detected by immunohistochemical staining (SP method) . Results 　The positive rates of COX-2 and BFGF, BFGFR were 59. 2 %, 69. 3 %, 65. 3 % in carcinoma of the colon and rectum respectively. The positive rates of COX-2 and BFGF were 30. 0 %, 40. 0 %, 35. 0 % in hyperplastic polyp of intestine respectively. The positive rates of COX-2 and BFGF, BFGFR were significant difference between in carcinoma of the colon and rectum and in hyperplastic polyp of intestine ( P < 0. 05) . There were significant correlation among the expression of COX-2 and BFGF, BFGFR and Dukes stage, lymphnode metastasis ( P < 0. 05) . There were no significant relationship between the COX-2 and BFGFR, but there were significant correlation between cox-2 and BFGF, BFGF and BFGFR. Conclusion 　Excessive expression of COX-2 and BFGF, BFGFR in carcinoma of the colon and rectum participates carcinogenesis. COX-2 and BFGF, BFGFR were related with prognosis ;COX22 was interdependent of BFGFR, but COX-2 and BFGF, BFGF and BFGFR synergismed in carcinoma of colon and rectum.