贲门癌中c-erbB-2、MTA1及E-cadherin的表达

Clinicopathological Study on c-erbB-2,Metastasis-associated Protein 1 (MTA1) and E-cadherin Expression in Gastric Cardia Cancer

摘要: 目的探讨c-erbB-2、MTA1及E-cadherin蛋白在贲门癌组织中的表达与肿瘤生物学行为的相关性,以及它们三者之间的相关性。方法采用免疫组织化学方法对60例贲门癌组织和18例癌旁组织中c-erbB-2、MTA1及E-cadherin蛋白的表达情况进行检测。结果c-erbB-2的表达与贲门癌的浸润、转移呈正相关,与分化程度呈负相关(P<0.05)。MTA1的表达与贲门癌的浸润深度无显著相关性,与贲门癌的淋巴结转移呈正相关,与分化程度呈负相关(P<0.05)。E-cadherin的表达与贲门癌的浸润深度、转移呈负相关(P<0.05),与分化程度无关。Spearman等级相关分析显示,c-erbB-2与MTA1的表达呈显著正相关(rs=0.276,P<0.05),MTA1与E-cadherin的表达呈负相关(rs=-0.293,P<0.05)。结论c-erbB-2与MTA1的高表达及E-cadherin的表达减少可能是促进贲门癌浸润和转移的重要因素。

Abstract: Objective To investigate the expression of c-erbB-2, MTA1 and E-cadherin and relationship between the expression of these proteins and the tumor biological behavior,as well as relationship between these proteins in gastric cardia cancer. Methods Immunohistochemical technique was used to detect the expression of c-erbB-2, MTA1 and E-cadherin among 60 gastric cardia cancer samples and 18 cases of adjacent mucosa tissue. Results c-erbB-2 over-expression was positively correlated with the depth of invasion, lymph...