Abstract: Objective 　To observe the response of Aiyishu associated NP regimen in the t reatment for nonsmall cell lung cancer (NSCLC) . Methods 　Seventy-six patients with NSCLC were randomly devided into treatment group (Aiyishu associated NP regimen) and control group (NP regimen ) to study the clinical effective rate and results of sensitive drug trial of tumor before and after treatment for both groups. Results 　The partial response rate was 60. 0 % in treatment group and 36. 1 % in cont rol group ( P < 0. 05) ; the overall disease control rate was 90. 0 % and 63. 9 % respectively. The effective rate of drug trial is 80. 0 % in t reatment group and 80. 6 % in cont rol group ( P > 0. 05) before t reatment and is 87. 5 % and 63. 9 % respectively af ter t reatment ( P < 0. 05) . Conclusion 　The regimen of Aiyishu associated NP is more effective and less toxicity one than NP regimen. It can improve the sensitive drug t rial of tumor and worths to further investigations in a large, multicenter climical study.