HIF-1α与MVD 在上皮性卵巢癌中的表达

doi:10.3971/j.issn.1000-8578.1528

HIF-1α与MVD 在上皮性卵巢癌中的表达

The Chinical Significance of HIF-1αand MVD Expression in Epithelial Ovarian Carcinoma

摘要

摘要: 目的探讨卵巢上皮性肿瘤中缺氧诱导因子-1α（HIF-1α）与微血管密度（MVD）的关系。方法采用原位杂交和免疫组化法检测66例卵巢上皮性肿瘤和正常卵巢组织中HIF-1α mRNA和蛋白的表达水平，用CD105标记MVD。结果 ①HIF-1α mRNA及HIF-1α在卵巢上皮癌和交界性肿瘤中的表达高于良性肿瘤和正常卵巢组织（P〈0．05）。CD105-MVD值呈卵巢上皮癌〉交界性肿瘤〉良性肿瘤（P〈0．05）。②HIF-1α 和CD105-MVD值明显正相关，且组织分化程度越低，表达越高（P〈0．05）。结论 HIF-1α对卵巢癌的发生、发展具有重要作用。

Abstract: Objective 　To study the relationship between the expression of hypoxia inducible factor-1α ( HIF-1α) and microvessel density (MVD) in epithelial ovarian tumors. Methods 　The 66 specimens of epithelial ovarian tumor and normal ovarian tissue samples were studied by SP immunohistochemical techniques and in situhybridization techniques to explore the expression of HIF-1α mRNA and protein, and the microvessel density marked by CD105. Results 　① The expression level of HIF-1αand HIF-1α mRNA in borderline and malignant ovarian tumors were higher than benign ovarian tumors and normal ovarian tissues ( P < 0. 05) . CD105-MVD is higher in malignant ovarian tumors than borderline and benign ovarian tumors ( P < 0. 05) . ② The correlation of HIF-1αand CD1052MVD was positive, and were negative with histological differentiation ( P < 0. 05) . Conclusion 　HIF-1αmay play an important role in occurrence and development of epithelial ovarian tumors.

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