Abstract: Objective 　To study the correlation between the multislice helical CT(MSCT) feature of tumor blood supply type in patients with hepatocellular carcinoma ( HCC) and the serum level of vascular endothelial growth factor (VEGF) . Methods 　According to the cont rast-enhanced characteristic of lesion on MSCT, the tumor blood supply in 60 patients with HCC were classified into different types such as arterial blood supply, portal blood supply, arteroportal blood supply, and poorly blood supply. Enzyme linked immunosorbent assay ( ELISA) was used to test the serum levels of VEGF collected from 20 healthy individuals and 60 patient s with HCC respectively. At last, the CT features of tumor blood supply type were performed statistical analysis with the serum levels of VEGF. Results 　The serum levels of VEGF in 20 patients with arterial blood supply type and 20 patients with arteroportal blood supply were significantly higher than that in 20 healthy individuals and 20 patients with portal blood supply or poorly blood supply type ( P < 0. 01) . There was no statistical significance of serum VEGF levels between 20 patients with portal blood supply or poorly blood supply type and 20 healthy individuals ( P > 0. 05) . Conclusion 　The pattern of tumor blood supply for HCC on MSCT is correlative with the serum level of VEGF, and it is of great value in the interventional therapy for HCC.