Abstract: Objective 　To explore the therapeutic effect, the toxic and side effects of xeloda capecitabine treatment in breast cancer after failure of combination therapy. Methods 　36 patients accepted the therapeutic alliance plan of xeloda monotherapy together with basic therapy. 2 500mg/ m² xeloda peros b. i. d, half hour after meals, two weeks applied and one week free, repeated in the fourth week. Effect evaluation was made af ter each two cycles, medicine discontinued when state of disease progressed. Basic therapy including nut ritional supporting therapy, anti-anemia therapy, anti-bone-metastasis therapy, alleviating pain therapy, etc, had been applied at equal pace. Results 　All patients had finished chemotherapy of more than 6 cycles. CR in 2 case, PR in 15 cases, SD in 11 case, PD in 8 cases. Effective rate was 47. 2 %, disease control rate was 77. 8 %, meso-life span without disease progressing was 8. 2 months. 1 year and 2 years survival rate was 66. 7 % and 25 % respectively. The main toxic and side effects observed were reversible hand-foot syndrome and skin pigmentation. Conclusion 　The treatment applying xeloda monotherapy has been proved still a fine choice in breast cancer when combination therapy defeated. The compliance, tolerance and safty are all good in patients.