GP方案与FLEP方案治疗晚期胰腺癌的疗效比较

Comparative study of gemcitabine plus cisplatin and FLEP regimen in the treatment of advanced pancreatic cancer

摘要: 目的比较ＧＰ（健择＋ＤＤＰ）与ＦＬＥＰ（ＣＦ、５－Ｆｕ、ＥＰＩ、ＤＤＰ）方案治疗晚期胰腺癌的近期疗效与不良反应。方法将４０例晚期胰腺癌随机分为治疗组和对照组，分别给予ＧＰ与ＦＬＥＰ方案化疗２个周期，按ＷＨＯ标准评定疗效和不良反应。结果两组有效率（ＣＲ＋ＰＲ）分别为３０％和１５％，治疗组高于对照组（Ｐ＜０．０５），两组的毒副反应相似。不良反应主要为骨髓抑制和胃肠道反应。结论健择加顺铂是治疗晚期胰腺癌的一种安全有效的化疗方案。

Abstract: Objective To compare the efficacy and toxicity of gemcitabine plus cisplatin and FLEP(5-fluorouracil,epirubicin and cisplatin) regimen for advanced pancreatic cancer. Methods The clinical data of 40 case with advanced pancreatic cancer treated with GP(20 cases ) and FLEP (20 cases) regimen were analysed . Results The response rate was 30% in patients with GP, 15% in those with FLEP regimen .The side effect and toxicity of two groups was similar.The main toxicity was myelosuppression and gastrointestinal tr...