Abstract: Objective To evaluate the efficacy and to toxicity of DDP combined with himonthly 5|Fu in the patients with advanced breast cancer. Methods The patients with a histologic diagnosis of breast cancer were eligible. All patients were treated with CMF/CAF and conventional radiotherapy. The chemotherapy regimen was comprised of bimonthly 2|hour infusion of leucovorin 200mg/m2 followed by 10|minute intravenous bolus of 5|Fu 375mg/m2, then 48|hour infusion of 5|Fu 3.0g/m2using an ambulatory pump, Cisplatm 25mg/m2d1-2infusion. Every 28 days one cycles. All pationts were received at least two cycles of treatment. Results After two cycles of chemotherapy. 2 obtained complete remission (CR) (5.6%), 18 obtained partial remission (PR) (50%), 10 had stable disease (SD) (27.7%). Nausea vomiting and myelosuppression were mainly side effects. Toxicity was comparatively mild. Conclusion Data from the current study indicated that bimonthly 5|Fu/LV combined with DDP had moderate activity but comparatively mild toxicity for advanced breast cancer.