胆囊胆汁癌胚抗原诊断大肠癌肝转移的临床意义

The Clinical Signification of CEA Value of Cholecytic Bile for Diagnosis of Colonic Cancer Metastased to liver

摘要: 目的　探讨胆囊胆汁癌胚抗原 (CEA)值诊断大肠癌肝转移的临床价值。方法　应用竞争放射免疫分析法共测定胆囊胆汁及同期血清CEA值 75例。共分为三组 :A组 (大肠癌组 ) 34例、B组 (术后肝转移组 ) 11例、C组 (良性疾病组 )为对照组 30例。胆汁标本于术中细针穿刺胆囊抽取 5ml, 血清标本于术晨采集静脉血 2ml。结果　胆汁CEA测定结果 :A组均值 ( 173 2± 2 5)ng ml;B组均值 ( 752± 117)ng ml;C组均值 ( 4 1 3± 2 8)ng ml。经统计学处理, A、B与C组比较有显著性差异P <0 0 1,A与B组比较有显著性差异P <0 0 1。血清CEA测定结果 :A组均值 ( 17 3± 2 7)ng ml;B组均值 ( 19 5± 4 3)ng ml ;C组均值 ( 11 3± 1 4 )ng ml。经统计学处理, A、B与C组比较有明显差异P <0 0 5。A与B组比较无明显差异P >0 0 5。结论　胆囊胆汁CEA值 >640ng ml时对诊断大肠癌肝转移有一定临床意义。

Abstract: Objective It explored the carcino-embryonic antigen(CEA)values of cholecystic bile to diagnose hepatic metastasis of the colonic cancer and to estimate its clinical significance. Methods Utilized competitive radio-immunoassay surveyed CEA simultaneously both cholecystic bile and serum of 75 cases.These cases divided into three groups.Group A(colonic cancer group)34 cases,Group B(postoperatively hepatic metastases of colonic carcinoma group)11 cases,Group C (Begin disease group)for controlled group 30 cases,t...