乳腺肿瘤中c-erbB-2和nm23蛋白的表达及临床意义

Expression of c-erbB-2 and nm23 Protein in Breast Neoplasm and Their Clinical Significance

摘要: 目的　研究c erbB 2和nm2 3基因蛋白在乳腺肿瘤中的表达情况及临床意义。方法应用免疫组化S P法, 对 131例乳腺良恶性肿瘤进行c erbB 2和nm2 3基因蛋白检测, 对其中 10 2例乳腺癌进行雌激素受体 (ER)和孕激素受体 (PR)检测。结果　c erbB 2蛋白在导管内癌、Paget病及浸润性导管癌中呈高表达 ;nm2 3蛋白在浸润性小叶癌中呈高表达。c erbB 2与淋巴结转移及PR呈正相关 ;nm2 3与乳腺癌患者的年龄、组织学分级、淋巴结转移及ER和PR密切相关。结论c erbB 2呈阴性表达、而nm2 3呈阳性表达时乳腺癌患者的预后最好。

Abstract: Objective To study the expression and clinical significance of c-erbB-2 and nm23 protein in breast neoplasm. Methods 131 cases of benign and malignant breast neoplasm were examined by immunohistochemical S-Pmethods.Among them,102 cases of breast carcinomas were examined for estrogen and progesterone receptor status. Results There was a high expression of c-erbB-2 in intraductal carcinoma,Pagets disease and infiltrating duct carcinoma. There was a high nm23 expression in infiltrating lobular carcinoma.There w...