高发区食管贲门癌前病变患病与食管癌家族遗传分析

An Epidemiologic Analysis of Precancerous Lesion in Esophageal and Cardiac with Esophageal Cancer Family Hereditary Factor in High Risk Areas

摘要: 目的　探讨食管贲门癌前病变与食管癌家族遗传的患病关系。方法　选择食管癌高发区 2 0 13例胃镜普查人群为分析资料, 分别计算食管贲门癌前病变与食管癌家族遗传阳性人群和阴性人群的患病危险度 (RR1)和特异危险度 (AR1) ;以及食管贲门癌前病变与食管癌家族遗传 1级亲属和 2级亲属的RR2 和AR2 。结果　RR1=1.38,95 %CI (1.11～ 1.72 ), AR1=2 7.5 % ;RR2 =1.76, 95 %CI (1.0 0～3.12 ), AR2 =4 3.2 %。结论　食管贲门癌家族遗传阳性人群, 食管癌前病变患病危险度高, 特别是遗传1级亲属。

Abstract: Objective To investigate the epidemiologic relation between the precancerous lesions in esophageal cardiac and the family hereditary factor. Methods Having analyzed the results of 2013 cases for endoscopic survey in high risk areas. Prevalence Relative risk (RR_1) and attribution risk (AR_1) of precancerous lesions were analyzed between positive mass with family hereditary in the esophageal cardiac cancer and negative mass. Simultaneously RR_2 and AR_2 analyzed between the first-degree relatives and the sec...