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摘要: 目的通过检测PCDGF在乳腺癌、乳腺纤维瘤中的表达及其与常用临床病理学指标的相关性,初步探索PCDGF在乳腺癌的诊断和生物靶向治疗中的意义。方法免疫组化法检测PCDGF在乳腺癌、乳腺纤维瘤中的表达及p53、c-erbB-2在乳腺癌中的表达,统计学检验其相关性。结果PCDGF表达于大多数乳腺癌组织而在乳腺纤维瘤中几乎不表达,PCDGF的表达与肿瘤病理类型、p53、ER/PR表达相关,而与c-erbB-2的表达无明显相关性。结论PCDGF可作为协助诊断乳腺癌的标记物之一,并参与乳腺癌的增殖和分化,有可能是乳腺癌生物靶向治疗的有效靶点。Abstract: Objective To evaluate the expression of PCDGF in breast cancer and breast adenofibroma and to compare with other commonly used clinical pathological index,and then to investigate the diagnositic and targetted therapeutic purpose of PCDGF in breast cancer tissues. Methods We detected the expression of PCDGF,p53 and cerbB-2 in breast cancer tissue and the expression of PCDGF in breast adenofibroma tissue by immunohistochemical method,and took statistics to analyze the association between them. Results PCDGF expressed in most breast cancer tissues, but there was no expression in breast adenofibroma tissue almostly, and the expression of PCDGF was related with tumor's pathological category and expression of ER/ PR and p53, but there was no statistical dependence between PCDGF and cerbB-2. Conclusion PCDGF might be a marker in assistanting diagnosis of breast cancer. It might participate in the generation and differentiation of breast cancer cell, and could come to be an effect therapy target in breast cancer.
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Key words:
- Growth factor /
- Breast carcinoma /
- Tumor markers
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