24例胃肠间质瘤病理及免疫组化分析

Pathologic and Immunohistochemical Aanalysis of 24 Cases of Gastrointestinal Stromal Tumor

摘要: 目的　探讨胃肠间质瘤病理诊断及免疫组化特点。方法　对 2 4例胃肠间质瘤进行常规病理及免疫组化CD117、CD34、SMA、S 10 0染色特点分析。结果　 2 4例胃肠间质瘤由梭形细胞和上皮样细胞组成, 其中 2 1例CD117和 18例CD34标记阳性, 阳性表达率分别为 87.5 %和 75 %。结论　胃肠间质瘤是胃肠常见的间叶性肿瘤, 缺乏定向分化。CD117和CD34标记阳性对胃肠间质瘤的诊断具有非常重要的价值

Abstract: Objective To investigate the pathologic and immunohistochemical features of CD117 CD34 SMA S-100 and diagnostic criteria of gastrointestinal stromal tumors(GIST). Methods 24 cases of GIST were studied by routine and immunohistochemistry. Results The GISTS showed two bases cell types spindle and epithelioid; 21 cases, tumor cells of GIST were positivery stained for CD117. 18 cases, tumor cells of GIST were positively stained for CD34. Conclusion GIST which have no evidence of specific differentiation con...