BAIAP2L1在宫颈癌中表达的临床意义及其对宫颈癌细胞恶性表型的影响

赵珏莹; 韩卓莹; 冯路路; 王晨龙; 张莉; 罗超; 王其龙

doi:10.3971/j.issn.1000-8578.2025.24.0951

BAIAP2L1在宫颈癌中表达的临床意义及其对宫颈癌细胞恶性表型的影响

Clinical Importance of BAIAP2L1 Expression in Cervical Cancer and Its Effect on Malignant Phenotype of Cervical Cancer Cells

摘要

摘要:
目的探讨BAIAP2L1在宫颈癌中的表达特征及其对肿瘤细胞转移的调控作用。
方法基于公共数据库分析BAIAP2L1表达与临床预后的相关性，通过R语言进行GO通路富集及临床病理关联分析。采用基因沉默技术观察BAIAP2L1敲低对宫颈癌细胞增殖、侵袭迁移及上皮间质转化（EMT）的影响。
结果 BAIAP2L1在宫颈癌组织中表达显著上调（P_adj<0.001），是患者死亡独立风险因素（HR=2.808，P=0.03），且与总生存期、T/N分期及复发转移显著相关（均P<0.05）。基因功能富集显示其参与肿瘤转移相关通路。敲低BAIAP2L1可显著抑制癌细胞增殖、侵袭迁移能力及EMT进程（均P<0.05）。
结论 BAIAP2L1在宫颈癌中表达上调，与不良预后及转移密切相关，靶向抑制该基因可有效遏制肿瘤进展。

Abstract:
Objective To explore the expression characteristics of BAIAP2L1 in cervical cancer (CC) and its regulatory role in tumor cell metastasis.
Methods The correlation between BAIAP2L1 expression and clinical prognosis was analyzed by using a public database. GO pathway enrichment and clinicopathological correlation analyses were conducted by employing R language. The effect of BAIAP2L1 knockdown on CC cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) were further investigated through gene silencing approaches.
Results BAIAP2L1 expression was significantly upregulated in CC tissues (P_adj<0.001) and it was identified as an independent risk factor for patient mortality (HR=2.808, P=0.03). Elevated BAIAP2L1 levels showed significant correlations with poor overall survival, advanced T/N stage, recurrence, and metastasis (all P<0.05). Functional enrichment analysis revealed its involvement in tumor metastasis-related pathways. The knockdown of BAIAP2L1 significantly attenuated CC cell proliferation, invasion, and migration and suppressed key EMT processes (all P<0.05).
Conclusion BAIAP2L1 is overexpressed in CC tissues and associated with patient prognosis and metastasis. The targeted inhibition of BAIAP2L1 can effectively curb tumor progression.

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