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摘要:
结直肠癌(CRC)是消化道常见的恶性肿瘤，近年来发病率和死亡率不断上升。它的发生发展开始于大肠、结肠和直肠内壁的良性腺瘤性息肉，可逐渐发展至晚期腺瘤原位癌和侵袭性癌。越来越多的研究表明长链非编码RNA(LncRNA)参与结直肠癌的多种调控机制，促进或抑制结直肠癌的发生发展。本文就结直肠癌相关的LncRNA的调控机制进行综述。
Abstract:Colorectal cancer (CRC) is a common malignant tumor in the digestive tract. In recent years, its incidence and mortality have been on the rise. It begins with benign adenomatous polyps on the inner walls of the large intestine, colon and rectum, and can gradually progress to advanced adenomatous carcinoma in situ and aggressive carcinoma. More and more studies have shown that LncRNA is involved in various regulatory mechanisms of colorectal cancer and promotes or inhibits the occurrence and development of colorectal cancer. This article reviews the regulatory mechanism of colorectal cancer-related LncRNA.
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Key words:
- Long non-coding RNA /
- Colorectal cancer /
- Regulatory mechanism
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Competing interests: The authors declare that they have no competing interests.作者贡献吴紫微：文献检索、文章构思和撰写谢圣高：文章构思、写作指导、审核及修改
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