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摘要:
环状RNA是一种非编码RNA，能作为RNA的海绵体调节剪切和转录，也能翻译蛋白质以及与RNA结合蛋白相互作用。近年来研究发现，环状RNA在肿瘤组织的表达异常与肺癌的发生、发展以及预后存在密切的关系，有望成为肺癌的诊断、治疗及预后的生物标志物。故本文对环状RNA作为肺癌生物标志物的研究进展作一综述。
Abstract:Circular RNA is a non-coding RNA that acts as a sponge for RNA, regulates cleavage and transcription, translates proteins and interacts with RNA-binding proteins. In recent years, studies have found that the abnormal expression of circular RNA in tumor tissues is closely related to the occurrence, development and prognosis of lung cancer and it is expected to be a biomarker for the diagnosis, treatment and prognosis of lung cancer. Therefore, this paper reviews the research progress of circular RNA as a biomarker of lung cancer.
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Key words:
- Circular RNA /
- Lung cancer /
- Biomarkers
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作者贡献萧志昊：收集资料、撰写论文肖瑶：承担论文的经费、设计、质量把关卢晓丹：撰写及修改论文李文丹：收集资料、撰写论文
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表 2 环状RNA与肺癌细胞增殖、凋亡、侵袭和迁移的关系
Table 2 Association between circular RNA and proliferation, apoptosis, invasion, migration of lung cancer cells
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[1] Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency[J]. Nature, 2013, 495(7441): 333-338. doi: 10.1038/nature11928
[2] Sanger HL, Klotz G, Riesner D, et al. Viroids are Single-Stranded Covalently Closed Circular RNA Molecules Existing as Highly Base-Paired Rod-Like Structures[J]. Proc Natl Acad Sci U S A, 1976, 73(11): 3852-3856. doi: 10.1073/pnas.73.11.3852
[3] Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats[J]. RNA, 2013, 19(2): 141-157. doi: 10.1261/rna.035667.112
[4] Zhang Y, Zhang XO, Chen T, et al. Circular Intronic Long Noncoding RNAs[J]. Mol Cell, 2013, 51(6): 792-806. doi: 10.1016/j.molcel.2013.08.017
[5] Conn SJ, Pillman KA, Toubia J, et al. The RNA binding protein quaking regulates formation of circRNAs[J]. Cell, 2015, 160(6): 1125-1134. doi: 10.1016/j.cell.2015.02.014
[6] Enuka Y, Lauriola M, Feldman ME, et al. Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor[J]. Nucleic Acids Res, 2016, 44(3): 1370-1383. doi: 10.1093/nar/gkv1367
[7] Jeck WR, Sharpless NE. Detecting and characterizing circular RNAs[J]. Nat Biotechnol, 2014, 32(5): 453-461. doi: 10.1038/nbt.2890
[8] Zhong Y, Du Y, Yang X, et al. Circular RNAs function as ceRNAs to regulate and control human cancer progression[J]. Mol Cancer, 2018, 17(1): 79. doi: 10.1186/s12943-018-0827-8
[9] Salzman J, Gawad C, Wang PL, et al. Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types[J]. PLoS One, 2012, 7(2): e30733. doi: 10.1371/journal.pone.0030733
[10] Petar Glažar, Panagiotis Papavasileiou, Rajewsky N. circBase: a database for circular RNAs[J]. RNA, 2014, 20(11): 1666-1670. doi: 10.1261/rna.043687.113
[11] Li M, Ding W, Sun T, et al. Biogenesis of circular RNAs and their roles in cardiovascular development and pathology[J]. FEBS J, 2018, 285(2): 220-232. doi: 10.1111/febs.2018.285.issue-2
[12] Floris G, Zhang L, Follesa P, et al. Regulatory Role of Circular RNAs and Neurological Disorders[J]. Molecular Neurobiology, 2017, 54(7): 5156-5165. doi: 10.1007/s12035-016-0055-4
[13] Ashwal-Fluss R, Meyer M, Pamudurti NR, et al. circRNA Biogenesis Competes with Pre-mRNA Splicing[J]. Mol Cell, 2014, 56(1): 55-66. doi: 10.1016/j.molcel.2014.08.019
[14] Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus[J]. Nat Struct Mol Biol, 2015, 22(3): 256-264. doi: 10.1038/nsmb.2959
[15] Zhang XO, Wang HB, Zhang Y, et al. Complementary Sequence-Mediated Exon Circularization[J]. Cell, 2014, 159(1): 134-147. doi: 10.1016/j.cell.2014.09.001
[16] Karreth FA, Pandolfi PP. ceRNA Cross-Talk in Cancer: When ce-bling Rivalries Go Awry[J]. Cancer Dis, 2013, 3(10): 1113-1121. doi: 10.1158/2159-8290.CD-13-0202
[17] Yang C, Yuan W, Yang X, et al. Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression[J]. Mol Cancer, 2018, 17(1): 19. doi: 10.1186/s12943-018-0771-7
[18] Zhang R, Xu J, Zhao J, et al. Silencing of hsa_circ_0007534 suppresses proliferation and induces apoptosis in colorectal cancer cells[J]. Eur Rev Med Pharmacol Sci, 2018, 22(1): 118-126. http://cn.bing.com/academic/profile?id=75861ee49365344cccfc6da22e8dc257&encoded=0&v=paper_preview&mkt=zh-cn
[19] Xu Y, Yao Y, Zhong X, et al. Downregulated circular RNA hsa_circ_0001649 regulates proliferation, migration and invasion in cholangiocarcinoma cells[J]. Biochem Biophys Res Commun, 2018, 496(2): 455-461. doi: 10.1016/j.bbrc.2018.01.077
[20] Zhu Q, Lu G, Luo Z, et al. CircRNA circ_0067934 promotes tumor growth and metastasis in hepatocellular carcinoma through regulation of miR-1324/FZD5/Wnt/β-catenin axis[J]. Biochem Biophys Res Commun, 2018, 497(2): 626-632. doi: 10.1016/j.bbrc.2018.02.119
[21] Huang XY, Huang ZL, Xu YH, et al. Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma[J]. Sci Rep, 2017, 7(1): 5428. doi: 10.1038/s41598-017-05432-8
[22] Han D, Li J, Wang H, et al. Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression[J]. Hepatology, 2017, 66(4): 1151-1164. doi: 10.1002/hep.29270
[23] Yang L, Wang J, Fan Y, et al. Hsa_circ_0046264 up-regulated BRCA2 to suppress lung cancer through targeting hsa-miR-1245[J]. Respir Res, 2018, 19(1): 115. doi: 10.1186/s12931-018-0819-7
[24] Zhang Y, Zhao H, Zhang L. Identification of the tumor-suppressive function of circular RNA FOXO3 in non-small cell lung cancer through sponging miR-155[J]. Mol Med Rep, 2018, 17(6): 7692-7700. http://cn.bing.com/academic/profile?id=cd587a09c65ce4d3a88ea80fb05d67a5&encoded=0&v=paper_preview&mkt=zh-cn
[25] Liu T, Song Z, Gai Y. Circular RNA circ_0001649 acts as a prognostic biomarker and inhibits NSCLC progression via sponging miR-331-3p and miR-338-5p[J]. Biochem Biophys Res Commun, 2018, 503(3): 1503-1509. doi: 10.1016/j.bbrc.2018.07.070
[26] Wang L, Liu S, Mao Y, et al. CircRNF13 regulates the invasion and metastasis in lung adenocarcinoma by targeting miR-93-5p[J]. Gene, 2018, pii: S0378-1119(18)30443-8.
[27] Wan L, Zhang L, Fan K, et al. Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/β-Catenin Pathway[J]. Biomed Res Int, 2016, 2016: 1579490. http://cn.bing.com/academic/profile?id=d457ba69ee909da3a16d3ad2a04e575c&encoded=0&v=paper_preview&mkt=zh-cn
[28] Li J, Wang J, Chen Z, et al. Hsa_circ_0079530 promotes cell proliferation and invasion in non-small cell lung cancer[J]. Gene, 2018, 665: 1-5. doi: 10.1016/j.gene.2018.04.059
[29] Yao JT, Zhao SH, Liu QP, et al. Over-expression of circRNA_100876 in non-small cell lung cancer and its prognostic value[J]. Pathol Res Pract, 2017, 213(5): 453-456. doi: 10.1016/j.prp.2017.02.011
[30] Jiang MM, Mai ZT, Wan SZ, et al. Microarray profiles reveal that circular RNA hsa_circ_0007385 functions as an oncogene in non-small cell lung cancer tumorigenesis[J]. J Cancer Res Clin Oncol, 2018, 144(4): 667-674. doi: 10.1007/s00432-017-2576-2
[31] Zhang S, Zeng X, Ding T, et al. Microarray profile of circular RNAs identifies hsa_circ_0014130 as a new circular RNA biomarker in non-small cell lung cancer[J]. Sci Rep, 2018, 8(1): 2878. doi: 10.1038/s41598-018-21300-5
[32] Wang X, Zhu X, Zhang H, et al. Increased circular RNA hsa_circ_0012673 acts as a sponge of miR-22 to promote lung adenocarcinoma proliferation[J]. Biochem Biophys Res Commun, 2018, 496(4): 1069-1075. doi: 10.1016/j.bbrc.2018.01.126
[33] Qiu M, Xia W, Chen R, et al. The circular RNA circPRKCI promotes tumor growth in lung adenocarcinoma[J]. Cancer Res, 2018, 78(11): 2839-2851. doi: 10.1158/0008-5472.CAN-17-2808
[34] Ding L, Yao W, Lu J, et al. Upregulation of circ_001569 predicts poor prognosis and promotes cell proliferation in non-small cell lung cancer by regulating the Wnt/β-catenin pathway[J]. Oncol Lett, 2018, 16(1): 453-458. http://cn.bing.com/academic/profile?id=494dce9b5c8e602bb543d34499dff76d&encoded=0&v=paper_preview&mkt=zh-cn
[35] Qi Y, Zhang B, Wang J, et al. Upregulation of circular RNA hsa_circ_0007534 predicts unfavorable prognosis for NSCLC and exerts oncogenic properties in vitro and in vivo[J]. Gene, 2018, 676: 79-85. doi: 10.1016/j.gene.2018.07.028
[36] Ma X, Yang X, Bao W, et al. Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis[J]. Biochem Biophys Res Commun, 2018, 498(4): 1009-1015. doi: 10.1016/j.bbrc.2018.03.105
[37] Luo YH, Zhu XZ, Huang KW, et al. Emerging roles of circular RNA hsa_circ_0000064 in the proliferation and metastasis of lung cancer[J]. Biomed Pharmacother, 2017, 96: 892-898. doi: 10.1016/j.biopha.2017.12.015
[38] 殷玉敬, 高辉, 郭佳, 等.环状RNA UBAP2沉默对肺癌A549细胞体外增殖和侵袭的影响及机制[J].中国肺癌杂志, 2017, 20(12): 800-807. doi: 10.3779/j.issn.1009-3419.2017.12.02 Yin Y, Gao H, Guo J, et al. Effect of Circular RNA UBAP2 Silencing on Proliferation and Invasion of Human Lung Cancer A549 Cells and Its Mechanism[J]. Zhongguo Fei Ai Za Zhi, 2017, 20(12): 800-807. doi: 10.3779/j.issn.1009-3419.2017.12.02
[39] Liu W, Ma W, Yuan Y, et al. Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302[J]. Biochem Biophys Res Commun, 2018, 500(4): 846-851. doi: 10.1016/j.bbrc.2018.04.172
[40] Han J, Zhao G, Mao X, et al. CircRNA circ-BANP-mediated miR-503/LARP1 signaling contributes to lung cancer progression[J]. Biochem Biophys Res Commun, 2018, 503(4): 2429-2435. doi: 10.1016/j.bbrc.2018.06.172
[41] Zhu X, Wang X, Wei S, et al. hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma[J]. FEBS J, 2017, 284(14): 2170-2182. doi: 10.1111/febs.2017.284.issue-14
[42] Zong L, Sun Q, Zhang H, et al. Increased expression of circRNA_102231 in lung cancer and its clinical significance[J]. Biomed Pharmacother, 2018, 102: 639-644. doi: 10.1016/j.biopha.2018.03.084
[43] Koh W, Pan W, Gawad C, et al. Noninvasive in vivo monitoring of tissue-specific global gene expression in humans[J]. Proc Natl Acad Sci U S A, 2014, 111(20): 7361-7366. doi: 10.1073/pnas.1405528111
[44] Bahn JH, Zhang Q, Li F, et al. The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva[J]. Clin Chem, 2015, 61(1): 221-230. doi: 10.1373/clinchem.2014.230433
[45] Lin X, Lo HC, Wong DT, et al. Noncoding RNAs in human saliva as potential disease biomarkers[J]. Front Genet, 2015, 6: 175. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=Doaj000004606340
[46] Dou Y, Cha DJ, Franklin JL, et al. Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes[J]. Sci Rep, 2016, 6: 37982. doi: 10.1038/srep37982
[47] Li Y, Zheng Q, Bao C, et al. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis[J]. Cell Res, 2015, 25(8): 981-984. doi: 10.1038/cr.2015.82
[48] 郭佳妮, 何敬东. circRNAs在肿瘤中的研究进展[J].肿瘤防治研究, 2016, 43(8): 728-730. doi: 10.3971/j.issn.1000-8578.2016.08.016 Guo JN, He JD. Research progress of circRNAs in cancer[J]. Zhong Liu Fang Zhi Yan Jiu, 2016, 43(8): 728-730. doi: 10.3971/j.issn.1000-8578.2016.08.016
