Relationship of Tumor Markers and Hilar Lymph Nodes with Bone Metastasis of Whole Body Bone Imaging in Lung Adenocarcinoma
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摘要:目的
探讨肺腺癌肿瘤标志物与骨转移之间的关系。
方法回顾性分析278例肺腺癌患者的全身骨显像，采用单因素Pearson卡方分析和Logistic二分类回归法对肺腺癌骨转移的相关因素进行分析。
结果（1）单因素卡方分析结果: CA125（p=0.000）、CYFRA21-1（p=0.000）、NSE（p=0.000）、SCC（p=0.036）、CEA（p=0.000）、ALp（p=0.000）、肺门淋巴节（p=0.000）均是骨转移的危险因素（均p < 0.05）；（2）二分类分析结果：CA125（p=0.009, OR=1.007）、NSE（p=0.012, OR=1.097）、ALp（p=0.001, OR=1.022）、CEA（p=0.013, OR=1.004）、肺门淋巴节（p=0.029, OR=2.136）是骨转移的危险因素（均p < 0.05, 均OR > 1），具有统计学意义; SCC（p=0.169, OR=1.194)、proGRp（p=0.703, OR=1.004）是骨转移的危险因素（均OR > 1），但不具统计学意义（均p > 0.05）。
结论CA125、NSE、ALP、CEA、肺门淋巴节与骨转移有关；SCC、ProGRP是骨转移的危险因素，但不具统计学意义；CYFRA21-1与骨转移无关。
Abstract:ObjectiveTo investigate the relationship between tumor markers of lung cancer and bone metastasis of whole body bone imaging in lung adenocarcinoma.
MethodsThe whole body bone imaging of 278 patients diagnosed as lung adenocarcinoma in our hospital was retrospectively analyzed. One-factor Pearson chi-square analysis and Logistic binary regression were used to analyze the relevant factors of bone metastasis of lung adenocarcinoma.
Results(1) One-factor chi-square analysis results showed that CA125, CYFRA21-1, NSE, SCC, CEA, ALP and hilar lymph nodes were risk factors for bone metastasis(all P < 0.05); (2) Binary Logistic analysis results showed that CA125, NSE, ALP, CEA and hilar lymph nodes were risk factors for bone metastasis(all P < 0.05, OR > 1); SCC and ProGRP were risk factors for bone metastasis, but without statistical significance(P > 0.05, OR > 1).
ConclusionCA125, NSE, ALP, CEA and hilar lymph nodes are risk factors for bone metastasis. SCC and ProGRP are risk factors for bone metastasis, but without statistically significance; CYFRA21-1 is not a risk factor for bone metastasis in lung adenocarcinoma.
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Key words:
- Lung adenocarcinoma /
- CA125 /
- CYFRA21-1 /
- NSE /
- CC /
- CEA /
- ProGRP /
- Hilar lymph nodes /
- Whole body bone imaging /
- Bone metastasis
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作者贡献曹仲年：负责论文的撰写及修改 郑 容：负责论文的审核 魏正茂、洪浩、关志梅、李玉焕：负责实验数据的审核
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