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恩度/贝伐单抗联合紫杉醇加铂类治疗晚期肺腺癌近期疗效对比观察

马会芳, 陆士新, 张伟杰, 王留兴

马会芳, 陆士新, 张伟杰, 王留兴. 恩度/贝伐单抗联合紫杉醇加铂类治疗晚期肺腺癌近期疗效对比观察[J]. 肿瘤防治研究, 2015, 42(01): 62-64. DOI: 10.3971/j.issn.1000-8578.2015.01.015
引用本文: 马会芳, 陆士新, 张伟杰, 王留兴. 恩度/贝伐单抗联合紫杉醇加铂类治疗晚期肺腺癌近期疗效对比观察[J]. 肿瘤防治研究, 2015, 42(01): 62-64. DOI: 10.3971/j.issn.1000-8578.2015.01.015
MA Huifang, LU Shixin, ZHANG Weijie, WANG Liuxing. Short-term Effect of Endostar/Bevacizumab in Combination with Paclitaxel and Platinum for Advanced Lung Adenocarcinoma[J]. Cancer Research on Prevention and Treatment, 2015, 42(01): 62-64. DOI: 10.3971/j.issn.1000-8578.2015.01.015
Citation: MA Huifang, LU Shixin, ZHANG Weijie, WANG Liuxing. Short-term Effect of Endostar/Bevacizumab in Combination with Paclitaxel and Platinum for Advanced Lung Adenocarcinoma[J]. Cancer Research on Prevention and Treatment, 2015, 42(01): 62-64. DOI: 10.3971/j.issn.1000-8578.2015.01.015

恩度/贝伐单抗联合紫杉醇加铂类治疗晚期肺腺癌近期疗效对比观察

详细信息
    作者简介:

    马会芳(1987-),女,硕士在读,主要从事肿瘤内科基础与临床研究

    通信作者:

    王留兴,E-mail:wlx2246@126.com

  • 中图分类号: R734.2

Short-term Effect of Endostar/Bevacizumab in Combination with Paclitaxel and Platinum for Advanced Lung Adenocarcinoma

  • 摘要: 目的 观察恩度/贝伐单抗联合化疗治疗晚期肺腺癌的近期疗效差异和安全性。方法 回顾性分析郑州大学第一附属医院自2010年1月至2013年6月晚期肺腺癌(ⅢB期或Ⅳ期)患者128例,其中单纯化疗组48例,恩度+化疗组(恩度组)44例,贝伐+化疗组(贝伐组)36例,运用χ2检验和Ridit分析,观察三组患者的近期疗效及安全性。结果 恩度组和贝伐组的客观缓解率和疾病控制率分别为31.8%、59.1%和36.1%、80.5%,均优于单纯化疗组(14.5%,39.5%)(P<0.05)。三组间的不良反应差异无 统计学意义(P>0.05)。结论 靶向药联合化疗治疗晚期肺腺癌疗效确切,不增加不良反应;在控制疾病进展方面贝伐单抗优于恩度。
    Abstract: Objective To observe the safety and short-term efficacy of endostar/bevacizumab combined with paclitaxel and platinum in the treatment for advanced lung adenocarcinoma. Methods We retrospectively analyzed 128 stage ⅢB and Ⅳ lung adenocarcinoma patients confirmed histologically from January 2010 to June 2013, 48 patients in the chemotherapy alone group, 44 patients in the endostar plus chemotherapy group(endostar group) and 36 patients in the bevacizumab plus chemotherapy group(bevacizumab group). Then we observed the short-term efficacy and safety by Chi-square test and Ridit analysis. Results The objective response rates (ORR) and disease control rates(DCR) of endostar group and bevacizumab group were 31.8%, 59.1% and 36.1%, 80.5% superior to those of chemotherapy alone group(14.5%, 39.5%) (P<0.05). There was no obvious difference in adverse reactions among three groups(P>0.05). Conclusion Targeted drug combined with chemotherapy has good curative effect in the treatment for advanced lung adenocarcinoma and the untoward effect was tolerable. Beacizumab is superior to endostar in controlling the progress of the disease.
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出版历程
  • 收稿日期:  2014-06-22
  • 修回日期:  2014-07-21
  • 刊出日期:  2015-01-24

目录

    Corresponding author: WANG Liuxing, wlx2246@126.com

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