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黏附分子CD24在卵巢癌中的研究进展

曾春燕, 陈 琦

曾春燕, 陈 琦. 黏附分子CD24在卵巢癌中的研究进展[J]. 肿瘤防治研究, 2014, 41(07): 844-847. DOI: 10.3971/j.issn.1000-8578.2014.07.034
引用本文: 曾春燕, 陈 琦. 黏附分子CD24在卵巢癌中的研究进展[J]. 肿瘤防治研究, 2014, 41(07): 844-847. DOI: 10.3971/j.issn.1000-8578.2014.07.034
ZENG Chunyan, CHEN Qi. Progress in Adhesion Molecule CD24 in Ovarian Cancer[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 844-847. DOI: 10.3971/j.issn.1000-8578.2014.07.034
Citation: ZENG Chunyan, CHEN Qi. Progress in Adhesion Molecule CD24 in Ovarian Cancer[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 844-847. DOI: 10.3971/j.issn.1000-8578.2014.07.034

黏附分子CD24在卵巢癌中的研究进展

基金项目: 江西省自然科学基金资助项目(20122DAB205053)
详细信息
    作者简介:

    曾春燕(1988-),女,硕士在读,主要从事妇科肿瘤的研究

    通信作者:

    陈琦, E-mail: chenqiyangbai@126.com

  • 中图分类号: R737.31

Progress in Adhesion Molecule CD24 in Ovarian Cancer

  • 摘要: 黏附分子CD24(cluster of differentiation 24)又称分化抗原簇蛋白,是一种高度糖基化蛋白,最初发现它参与了B细胞的发育。之后,越来越多的研究发现CD24在肿瘤形成和转移中也有重要作用。它在造血系统肿瘤及实体瘤如肝癌、肺癌、前列腺癌、乳腺癌、肾小管癌等多种肿瘤中高度表达,参与了肿瘤细胞的增殖、侵袭和转移。研究发现CD24在卵巢癌中也大量表达,随着卵巢癌中CD24研究的深入,将有助于揭示卵巢癌发病的分子机制,研发有效的抗肿瘤药物,提高卵巢癌患者的生存率。

     

    Abstract: Adhesion molecule cluster of differentiation 24(CD24), also known as differentiation antigen cluster protein, is a highly glycosylated protein, originally was discovered involving in B cell development. Thereafter, more and more researches find that CD24 also has an important role in tumor formation and metastasis. It is highly expressed in hematologic malignancies and solid tumors, such as liver cancer, lung cancer, prostate cancer, breast cancer, renal tubular cancer, etc., participating in tumor cell proliferation, invasion and metastasis. We find that CD24 is also highly expressed in ovarian cancer. Further research of CD24 in ovarian cancer will help to identify the molecular mechanisms of ovarian cancer, research and develop the effective anticancer drugs, improve the survival rate of patients with ovarian cancer.

     

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出版历程
  • 刊出日期:  2014-07-24

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