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肿瘤相关巨噬细胞在肿瘤发展及治疗中的作用

孙 鹏, 王艳林

孙 鹏, 王艳林. 肿瘤相关巨噬细胞在肿瘤发展及治疗中的作用[J]. 肿瘤防治研究, 2014, 41(07): 829-833. DOI: 10.3971/j.issn.1000-8578.2014.07.031
引用本文: 孙 鹏, 王艳林. 肿瘤相关巨噬细胞在肿瘤发展及治疗中的作用[J]. 肿瘤防治研究, 2014, 41(07): 829-833. DOI: 10.3971/j.issn.1000-8578.2014.07.031
SUN Peng, WANG Yanlin. Tumor-associated Macrophages Development and Treatment of Tumor[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 829-833. DOI: 10.3971/j.issn.1000-8578.2014.07.031
Citation: SUN Peng, WANG Yanlin. Tumor-associated Macrophages Development and Treatment of Tumor[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 829-833. DOI: 10.3971/j.issn.1000-8578.2014.07.031

肿瘤相关巨噬细胞在肿瘤发展及治疗中的作用

基金项目: 国家自然科学基金资助项目(30973445)
详细信息
    作者简介:

    孙鹏(1983-),男,硕士在读,主要从事肿瘤相关靶向治疗的研究

    通信作者:

    王艳林, E-mail: fzswangyl@ctgu.edu.cn

  • 中图分类号: R730.1;R730.3

Tumor-associated Macrophages Development and Treatment of Tumor

  • 摘要: 巨噬细胞在不同的刺激因子作用下能够分化为具有抗肿瘤活性的M1型巨噬细胞和具有促肿瘤活性的M2型巨噬细胞。肿瘤组织中的巨噬细胞主要为M2型,它们参与肿瘤的发生、发展、侵袭和转移等过程。特定的刺激可将M2型巨噬细胞逆向分化为M1型巨噬细胞,由此抑制肿瘤的生长。本文将对肿瘤相关巨噬细胞的分化及与肿瘤的密切关系作简要综述。

     

    Abstract: Macrophages affected by different simulating factors can be differentiated into M1-type macrophages with anti-tumor activity and M2-type macrophages with tumor-promoting activity. Main macrophages in tumor tissue are M2-type and they are involved in the process of tumor genesis, development, invasion and metastasis. Specific stimulation can re-differentiate M2-type macrophages into M1-type, thereby to inhibit tumor growth. This article briefly reviews the differentiation of tumor-associated macrophage and its close relationship with tumor.

     

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出版历程
  • 刊出日期:  2014-07-24

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