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睾丸生殖细胞肿瘤病因学研究进展

秦晓东, 袁欣然综述, 李冬梅, 韩晓冬审校

秦晓东, 袁欣然综述, 李冬梅, 韩晓冬审校. 睾丸生殖细胞肿瘤病因学研究进展[J]. 肿瘤防治研究, 2014, 41(07): 825-828. DOI: 10.3971/j.issn.1000-8578.2014.07.030
引用本文: 秦晓东, 袁欣然综述, 李冬梅, 韩晓冬审校. 睾丸生殖细胞肿瘤病因学研究进展[J]. 肿瘤防治研究, 2014, 41(07): 825-828. DOI: 10.3971/j.issn.1000-8578.2014.07.030
QIN Xiaodong, YUAN Xinran, LI Dongmei, HAN Xiaodong. Advances on Etiology of Testicular Germ Cell Tumors[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 825-828. DOI: 10.3971/j.issn.1000-8578.2014.07.030
Citation: QIN Xiaodong, YUAN Xinran, LI Dongmei, HAN Xiaodong. Advances on Etiology of Testicular Germ Cell Tumors[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 825-828. DOI: 10.3971/j.issn.1000-8578.2014.07.030

睾丸生殖细胞肿瘤病因学研究进展

基金项目: :国家自然科学基金资助项目(21377052);江苏省自然科学基金资助项目(BK20131281);南京大学大学生创新创业训练计划项目资助课题(G1210284113)
详细信息
    作者简介:

    秦晓东(1991-),男,硕士在读,主要从事生殖系统肿瘤发生发展机制研究

    通信作者:

    李冬梅,E-mail:lidm@nju.edu.cn

  • 中图分类号: R737.21;R730.2

Advances on Etiology of Testicular Germ Cell Tumors

  • 摘要: 睾丸生殖细胞肿瘤(TGCTs)是工业化国家年轻男性常见的恶性肿瘤之一,由于肿瘤大多形成于胎儿发育阶段,深入了解TGCTs的发病机制比较困难。本文探讨了TGCTs发病的相关因素,包括种族、地理与环境、基因与信号通路、癌干细胞、精原细胞微环境等,从而为探究TGCTs的发病机制提供基础,并为TGCTs的治疗开拓思路。

     

    Abstract: Testicular germ cell tumor (TGCT) is one of the commonest malignant tumors among young men in industrialized countries. As most tumors are formed in fetal development stage, it is difficult to have an insight into the pathogenesis. By reviewing the recent related reports, we discussed several etiologic factors of TGCTs, including race, geography, environment, related genes and signaling pathways, cancer stem cells (CSC), the niche for spermatogonial stem cells (SSCs), etc, to support investigating pathogenesis and treatment of TGCTs.

     

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  • 刊出日期:  2014-07-24

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