高级搜索

质谱分析及其在肺癌分子标志物研究中的应用

陈立如, 徐建军, 魏益平

陈立如, 徐建军, 魏益平. 质谱分析及其在肺癌分子标志物研究中的应用[J]. 肿瘤防治研究, 2014, 41(07): 820-824. DOI: 10.3971/j.issn.1000-8578.2014.07.029
引用本文: 陈立如, 徐建军, 魏益平. 质谱分析及其在肺癌分子标志物研究中的应用[J]. 肿瘤防治研究, 2014, 41(07): 820-824. DOI: 10.3971/j.issn.1000-8578.2014.07.029
CHEN Liru, XU Jianjun, WEI Yiping. Progress in Mass Spectrometry and Its Application in Lung Cancer Biomarker Research[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 820-824. DOI: 10.3971/j.issn.1000-8578.2014.07.029
Citation: CHEN Liru, XU Jianjun, WEI Yiping. Progress in Mass Spectrometry and Its Application in Lung Cancer Biomarker Research[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 820-824. DOI: 10.3971/j.issn.1000-8578.2014.07.029

质谱分析及其在肺癌分子标志物研究中的应用

基金项目: 国家自然科学基金资助项目(81160293);国家重大科学仪器设备开发专项基金资助项目(2011YQ170067)
详细信息
    作者简介:

    陈立如(1986-),男,硕士,医师,主要从事心胸外科围术期处理、质谱分析在肿瘤诊断中应用的研究

    通信作者:

    徐建军,E-mail:jianjun6307@163.com

  • 中图分类号: R734.2

Progress in Mass Spectrometry and Its Application in Lung Cancer Biomarker Research

  • 摘要: 常压直接质谱分析技术和质谱成像技术是近年来质谱分析的重要进展,它们在生物样品分析中具有广泛应用价值。肺癌是最常见的恶性肿瘤之一,早期筛查和诊断是改善其临床诊治现状的重要途径。本文就质谱分析及其在肺癌分子标志物研究中的应用作一综述。

     

    Abstract: Ambient mass spectrometry (AMS) and mass spectrometry imaging (MSI) are two major progresses in mass spectrometry (MS) in recent years, with a wide range of applications in research of biological samples. Lung cancer is one of the most common malignancies in the world. Early screening and diagnosis are the most important ways to change the severe situation. This paper mainly summarizes the progress of mass spectrometry and its application in lung cancer biomarker research.

     

  • [1] Chen HW,Hu B,Zhang X.Fundamental principles and practical applications of ambient ionization mass spectrometry for direct analysis of complex samples[J]. Fen Xi Hua Xue, 2010,38(8):1069-88. [陈焕文,胡斌,张燮.复杂样品质谱分 析技术的原理与应用[J].分析化学,2010,38(8):1069-88.]
    [2] Jemal A,Bray F,Center MM,et al.Global cancer statistics[J].CA Cancer J Clin,2011,61(2):69-90.
    [3] Detterbeck FC,Boffa DJ,Tanoue LT.The new lung cancer staging system[J].Chest J,2009,136(1):260-71.
    [4] Van’t Westeinde SC, van Klaveren RJ. Screening and early detection of lung cancer[J]. Cancer J, 2011, 17(1):3-10.
    [5] Takáts Z,Wiseman JM,Gologan B,et al.Mass spectrometry sampling under ambient conditions with desorption electrospray ionization[J]. Science, 2004, 306(5695):471-3.
    [6] Jia B,Zhang XL,Ding JH,et al.Principle and applications of extractive electrospray ionization mass spectrometry [J]. Ke Xue Tong Bao,2012,57(20):1918-27.[ 贾滨,张兴磊,丁健桦,等.电 喷雾萃取电离质谱技术及其应用进展[J].科学通报,2012, 57 (20):1918-27.]
    [7] Chen H,Yang S,Wortmann A,et al.Neutral desorption sampling of living objects for rapid analysis by extractive electrospray ionization mass spectrometry[J].Angew Chem Int Ed Engl,2007, 46 (40):7591-4.
    [8] Hiraoka K,Nishidate K,Mori K,et al.Development of probe electrospray using a solid needle[J].Rapid Commun Mass Spectrom, 20 07,21(18):3139-44.
    [9] Jia B,Ouyang Y,Sodhi RN,et al.Differentiation of human kidney stones induced by melamine and uric acid using surface desorption atmospheric pressure chemical ionization mass spectrometry[J].J Mass Spectrom,2011,46(3):313-9.
    [10] Dill AL,Eberlin LS,Zheng C,et al.Multivariate statistical differentiation of renal cell carcinomas based on lipidomic analysis by ambient ionization imaging mass spectrometry[J]. Anal Bioanal Chem,2010,398(7-8):2969-78.
    [11] Xiong XC,Fang X,Ouyang Z,et al.A new software for reconstituting mass spectra imaging data[J].Zhi Pu Xue Bao,2011,32(3):181-4.[熊行创,方向,欧阳证,等.质谱成像数据图 像重构软件[J].质谱学报,2011,32(3):181-4.]
    [12] Lagarrigue M,Lavigne R,Guével B,et al.Matrix-assisted laser desorption/ionization imaging mass spectrometry:a promising technique for reproductive research[J].Biol Reprod,2012, 86 (3):74.
    [13] Yang F,Yuan J,Zheng JJ,et al.Advances of imaging mass spectrometry based on MALDI-TOF[J].Fen Xi Yi Qi,2010,3:1-7. [杨帆,原剑,郑俊杰,等.MALDI-TOF生物质谱成像技术的进展 [J] 分析仪器,2010,3:1-7.]
    [14] Masterson TA,Dill AL,Eberlin LS,et al. Distinctive glycerophospholipid profiles of human seminoma and adjacent normal tissues by desorption electrospray ionization imaging mass spectrometry[J].J Am Soc Mass Spectrom,2011,22(8):1326-33.
    [15] Chen LC,Yoshimura K,Yu Z,et al.Ambient imaging mass spectrometry by electrospray ionization using solid needle as sampling probe[J].Mass Spectrom,2009,44(10):1469-77.
    [16] Harris GA,Galhena AS,Fernández FM.Ambient sampling/ ionization mass spectrometry: applications and current trends[J]. Anal Chem,2011,83(12):4508-38.
    [17] Xu W,Manicke NE,Cooks GR,et al. Miniaturization of mass spectrometry analysis systems[J].JALA Charlottesv Va,2010, 15 (6):433-9.
    [18] Riedo A,Bieler A,Neuland M,et al.Performance evaluation of a miniature laser ablation time-of-flight mass spectrometer designed for in situ investigations in planetary space research[J].J Mass Spectrom,2013,48(1):1-15.
    [19] Mazzone PJ.Analysis of volatile organic compounds in the exhaled breath for the diagnosis of lung cancer[J].J Thorac Oncol,2008, 3( 7):774-80.
    [20] Gordon SM,Szidon JP,Krotoszynski BK,et al. Volatile organic compounds in exhaled air from patients with lung cancer[J].Clin Chem,1985,31(8):1278-82.
    [21] Wang Y,Hu Y,Wang D,et al. The analysis of volatile organic compounds biomarkers for lung cancer in exhaled breath, tissues and cell lines[J].Cancer Biomark,2012,11(4):129-37.
    [22] Montuschi P,Mores N,Trové A,et al.The electronic nose in respiratory medicine[J].Respiration,2013,85(1):72-84.
    [23] Rutter AV,Chippendale TW,Yang Y,et al. Quantification by SIFTMS of acetaldehyde released by lung cells in a 3D model[J]. Analyst,2013,138(1):91-5.
    [24] Ding J,Yang S,Liang D,et al. Development of extractive electrospray ionization ion trap mass spectrometry for in vivo breath analysis[J].Analyst,2009,134(10):2040-50.
    [25] Brightling CE. Clinical applications of induced sputum[J]. Chest J, 20 06,129(5):1344-8.
    [26] Xiao H,Zhang L,Zhou H,et al. Proteomic analysis of human saliva from lung cancer patients using two-dimensional difference gel electrophoresis and mass spectrometry[J].Mol Cell Proteomics, 20 12,11(2):M111.012112.
    [27] Wei YP,Yan FY,Jia B,et al. Diagnosis of NSCLC on sputum by neutral desorption extractive electrospray ionization tandem mass spectrometry[J]. Zhong Hua Shi Yan Wai Ke Za Zhi, 2011, 28 (3):422-4.[魏益平,鄢飞燕,贾滨,等.痰液直接电喷雾萃取电离 质谱分析在非小细胞肺癌诊断中的应用[J].中华实验外科杂志, 20 11,28(3):422-4.]
    [28] Oh JM,Brichory F,Puravs E,et al.A database of protein expression in lung cancer[J].Proteomics,2001,1(10):1303-19.
    [29] Rahman SM,Shyr Y,Yildiz PB,et al.Proteomic patterns of preinvasive bronchial lesions[J].Am J Respir Crit Care Med, 20 05,172(12):1556-62.
    [30] Li B,Chang J,Chu Y,et al.Membrane proteomic analysis comparing squamous cell lung cancer tissue and tumor-adjacent normal tissue[J].Cancer Lett,2012,319(1):118-24.
    [31] Lee GK,Lee HS,Park YS,et al.Lipid MALDI profile classifies nonsmall cell lung cancers according to the histologic type[J].Lung Cancer,2012,76(2):197-203.
    [32] Singhal S,Vachani A,Antin-Ozerkis D,et al. Prognostic implications of cell cycle, apoptosis, and angiogenesis biomarkers in non-small cell lung cancer: a review[J].Clin Cancer Res,2005, 11 (11): 3974-86.
    [33] Huang W,Ding X,Li B,et al.Serum biomarkers analyzed by LCMS/ MS as predictors for short outcome of non-small cell lung cancer patients treated with chemoradiotherapy[J].Neoplasma, 20 13,60(1):11-8.
    [34] Guo Y,Wang X,Qiu L,et al.Probing gender-specific lipid metabolites and diagnostic biomarkers for lung cancer using Fourier transform ion cyclotron resonance mass spectrometry[J]. Clin Chim Acta,2012, 414:135-41.
计量
  • 文章访问数:  1657
  • HTML全文浏览量:  415
  • PDF下载量:  1669
  • 被引次数: 0
出版历程
  • 刊出日期:  2014-07-24

目录

    /

    返回文章
    返回
    x 关闭 永久关闭