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多西他赛微球体在腹膜转移癌中的治疗作用

韩龙海, 崔 雄

韩龙海, 崔 雄. 多西他赛微球体在腹膜转移癌中的治疗作用[J]. 肿瘤防治研究, 2014, 41(07): 711-713. DOI: 10.3971/j.issn.1000-8578.2014.07.005
引用本文: 韩龙海, 崔 雄. 多西他赛微球体在腹膜转移癌中的治疗作用[J]. 肿瘤防治研究, 2014, 41(07): 711-713. DOI: 10.3971/j.issn.1000-8578.2014.07.005
HAN Longhai, CUI Xiong. Therapeutic Effects of Docetaxel Microspheres on Peritoneal Metastatic Carcinoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 711-713. DOI: 10.3971/j.issn.1000-8578.2014.07.005
Citation: HAN Longhai, CUI Xiong. Therapeutic Effects of Docetaxel Microspheres on Peritoneal Metastatic Carcinoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 711-713. DOI: 10.3971/j.issn.1000-8578.2014.07.005

多西他赛微球体在腹膜转移癌中的治疗作用

详细信息
    作者简介:

    韩龙海(1967-),男,博士,主治医师,主要从事消化道恶性肿瘤的防治

  • 中图分类号: R73-36;R735.5

Therapeutic Effects of Docetaxel Microspheres on Peritoneal Metastatic Carcinoma

  • 摘要: 目的 探讨新的抗肿瘤药物剂型-多西他赛微球体(D-MS)在消化道恶性肿瘤所致腹膜转移癌中的治疗效果。方法 将220只BDF1小鼠分为11组,用B-16 Melanoma溶液注射后,经过4天形成腹膜转移癌,分别注入不同剂型及剂量的多西他赛,使用小样本计数的χ2检验,分析各组小鼠的平均生存期。结果 在D-MS组,随着多西他赛含量的增加,生存期也随之增加。在100 mg/kg组,平均生存期为28.9天,在400 mg/kg组,平均生存期达到114天。而在多西他赛水溶液组,随着多西他赛含量的增加,平均生存期并未随之增加,在多西他赛含量100 mg/kg组,平均生存期为28天,而在200 mg/kg 组,平均生存期也仅为29天。结论 D-MS可以作为新的抗肿瘤剂型用于腹膜转移癌的治疗中。

     

    Abstract: Objective To investigate the therapeutic effects of Docetaxel microspheres (D-MS), a new antitumor drug dosage form, on peritoneal metastatic carcinoma. Methods Two hundred and twenty BDF1 mice were divided into 11 groups, receiving intraperitoneal inoculation with B-16 PC melanoma for 4 days, until peritoneal metastatic carcinoma was formed. Docetaxel was administered with different formulations and doses. Average survival time was analyzed by chi-square test. Results D-MS extended the survival of mice with increasing dose of docetaxel. The average survival time of 100 and 400 mg/kg group were 28.9 and 114 days. While no significant effect was on aqueous solution of docetaxel group, as the average survival time of 100 and 200 mg/kg group were 28 and 29 days. Conclusion D-MS could be used as a new antitumor drug dosage form in the treatment of peritoneal metastatic carcinoma.

     

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出版历程
  • 刊出日期:  2014-07-24

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