高级搜索

RNA干扰技术抑制涎腺腺样囊性癌的研究进展

李 战, 农晓琳

李 战, 农晓琳. RNA干扰技术抑制涎腺腺样囊性癌的研究进展[J]. 肿瘤防治研究, 2014, 41(06): 689-692. DOI: 10.3971/j.issn.1000-8578.2014.06.040
引用本文: 李 战, 农晓琳. RNA干扰技术抑制涎腺腺样囊性癌的研究进展[J]. 肿瘤防治研究, 2014, 41(06): 689-692. DOI: 10.3971/j.issn.1000-8578.2014.06.040
LI Zhan, NONG Xiaolin. Research Progress of RNA Interference Inhibiting Salivary Adenoid Cystic Carcinoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(06): 689-692. DOI: 10.3971/j.issn.1000-8578.2014.06.040
Citation: LI Zhan, NONG Xiaolin. Research Progress of RNA Interference Inhibiting Salivary Adenoid Cystic Carcinoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(06): 689-692. DOI: 10.3971/j.issn.1000-8578.2014.06.040

RNA干扰技术抑制涎腺腺样囊性癌的研究进展

基金项目: 国家自然科学基金资助项目(30060082, 8136 0 4 0 4 );教育部“ 春晖计划” 科研启动基金( 教外司留[2003]593-7);广西自然科学基金重点项目(2010GXNSFD013047);广西科学基金资助项目(桂科回0836013);广西卫生厅重点科研项目(重200006,重200927);广西教育厅立项项目(2006-64)
详细信息
    作者简介:

    李战(1987-),男,硕士在读,主要从事口腔颌面部肿瘤的防治研究

    通信作者:

    农晓琳,E-mail:lab.nong@gmail.com

  • 中图分类号: R739.87

Research Progress of RNA Interference Inhibiting Salivary Adenoid Cystic Carcinoma

  • 摘要: 涎腺腺样囊性癌是头颈部常见的恶性肿瘤之一,具有早期易血行转移,嗜神经侵袭,术后易局部复发及远处转移等特点。目前,对丧失手术机会的患者尚缺乏有效的治疗手段。RNA干扰作为一种可高效、特异性沉默目的基因的手段已被广泛应用于各种肿瘤研究。通过利用RNA干扰技术沉默腺样囊性癌的癌基因、抗凋亡因子及黏附、迁移相关因子等基因的表达后,腺样囊性癌的发展受到了明显的抑制。本文拟对涎腺腺样囊性癌的RNA干扰治疗进展进行综述。

     

    Abstract: Salivary adenoid cystic carcinoma (SACC) is one of the common types of malignancies in head neck region.With high aggressive potential,SACC tends to invade blood vessels and nerves at an early stage and is prone to recurrence and distant metastasis.Yet, there are no effective therapies for patients in the late stages which have no indication for operation.RNA interference (RNAi) is a gene-silencing technology, resulting in the sequence-specifi c silence of target gene effi ciently and specifi cally. It has been applied widely in the research of various tumors. RNAi technology has been successfully used to inhibit SACC by suppressing the expression of oncogenes, anti-apoptotic factors and factors associated with adhesion and metastasis. This review describes current research progress of RNA interference inhibiting salivary adenoid cystic carcinoma.

     

  • [1] Wang YL,Zhu YX,Chen TZ,et al.Clinicopathologic study of 1176 salivary gland tumors in a Chinese population: experience of one cancer center 1997-2007[J].Acta Otolaryngol,2012,132(8):879-86.
    [2] Boukheris H,Curtis RE,Land CE,et al.Incidence of carcinoma of the major salivary glands according to the WHO classification, 19 92 to 2006: a population-based study in the United States[J]. Cancer Epidemiol Biomarkers Prev,2009,18(11):2899-906.
    [3] Al-Mamgani A,van Rooij P,Sewnaik A,et al.Adenoid cystic carcinoma of parotid gland treated with surgery and radiotherapy: long-term outcomes, QoL assessment and review of the literature[J],Oral Oncol,2012,48(3):278-83.
    [4] Wang Z,Rao DD,Senzer N,et al.RNA interference and cancer therapy[J].Pharm Res,2011,28(12):2983-95.
    [5] Tomek M,Akiyama T,Dass CR.Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy[J].J Pharm Pharmacol,2012,64(12):1695-702.
    [6] Zhang FJ,Ji P, Yang K,et al.Effect of recombined RNAi plasmids on apoptosis of cisplatin-resistant cell line Acc-3/CDDP[J]. Chongqing Yi Ke Da Xue Xue Bao,2009,34(6):680-3.[张福军,季 平,杨凯,等.Bcl-2重组干扰质粒促进多药耐药Acc-3/CDDP细胞 凋亡实验研究[J].重庆医科大学学报, 2009,34(6):680-3.]
    [7] Yu LJ,Wang J,Dong FS,et al.Effect of shRNA-medicated silence of H-ras gene onproliferation of human SACC-M cells[J].Zhonghua Kou Qiang Yi Xue Za Zhi,2008,43(2):113-7.[于利洁,王洁,董福 生,等.短发夹状RNA沉默H-ras基因对人涎腺腺样囊性癌细胞 增殖的影响[J].中华口腔医学杂志,2008,43(2):113-7.]
    [8] Huang HY,Cheng YY,Liao WC,et al.SOX4 transcriptionally regulates multiple SEMA3/plexin family members and promotes tumor growth in pancreatic cancer[J].PLoS One,2012,7(12): e48637.
    [9] Pramoonjago P,Baras AS.Moskaluk CA.Knockdown of Sox4 expression by RNAi induces apoptosis in ACC3 cells[J].Oncogene, 20 06,25(41):5626-39.
    [10] Okamoto K,Okamoto I,Hatashita E,et al.Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin[J]. Mol Cancer Ther,2012,11(1):204-13.
    [11] Chen XQ,Yang S,Li ZY,et al.Effects and mechanism of downregulation of survivin expression by RNA interference on proliferation and apoptosis of lung cancer cells[J].Mol Med Rep,2012,5(4):917-22.
    [12] Wang X,Yang J,Xu B,et al.Effects of survivin gene silencing on growth and apoptosis of adenoid cystic carcinoma cell line[J]. Di San Jun Yi Da Xue Xue Bao,2009,31(11):1053-6. [汪欣,杨军,许 波,等.survivin基因沉默对腺样囊性癌细胞生长和凋亡的影响 [J] 第三军医大学学报,2009,31(11):1053-6.]
    [13] Yang J,Wang X,Xu B,et al.Survivin small interfering RNA suppresses the growth of adenoid cystic carcinoma cell xenografts in vivo[J].Hua Xi Kou Qiang Yi Xue Za Zhi,2009,27(4):433-5. [杨军,汪欣,许波,等.生存素小干扰RNA对人腺样囊性癌 ACC-2细胞移植瘤体生长的抑制作用[J].华西口腔医学杂 志,2009,27(4):433-5.]
    [14] Wang JF,She L,Su BH,et al.CDH12 promotes the invasion of salivary adenoid cystic carcinoma[J].Oncol Rep,2011,26(1):101-8.
    [15] Xu Q,Liu X,Cai Y,et al.RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells[J].Tumour Biol,2010,31(3):217-24.
    [16] Xu Q, Liu X, Chen W,et al.Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference[J].J Transl Med,2010,8:136.
    [17] Xie W,Li X,Ren G,et al.Expression and importance of inhibitor of DNA binding helix-loop-helix protein in salivary adenoid cystic carcinoma[J].Br J Oral Maxillofac Surg,2010,48(6):434-7.
    [18] Liu P,Liu S,Qi H,et al.Effects of silencing Id-1 in cell culture of human adenoid cystic carcinoma[J].Oral Oncol,2009,45(9):783-8.
    [19] Chen Z,Liu S,Sumida T,et al.Silencing Id-1 with RNA interference inhibits adenoid cystic carcinoma in mice[J].J Surg Res,2011,169(1):57-66.
    [20] Yang X,Dai J,Li T,et al.Expression of EMMPRIN in adenoid cystic carcinoma of salivary glands: correlation with tumor progression and patients' prognosis[J].Oral Oncol,2010,46(10):755-60.
    [21] Yang X,Zhang P,Ma Q,et al.EMMPRIN contributes to the in vitro invasion of human salivary adenoid cystic carcinoma cells[J]. Oncol Rep,2012,27(4):1123-7.
    [22] Yang X,Zhang P,Ma Q,et al.EMMPRIN silencing inhibits proliferation and perineural invasion of human salivary adenoid cystic carcinoma cells in vitro and in vivo[J].Cancer Biol Ther,2012,13(2):85-91.
    [23] Jiang T,Zhuang J,Duan H,et al.CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis[J].Blood,2012,120(11):2330-9.
    [24] Chen W,Zhang HL,Jiang YG,et al.Inhibition of CD146 gene expression via RNA interference reduces in vitro perineural invasion on ACC-M cell[J].J Oral Pathol Med,2009,38(2):198-205.
    [25] Keikhaee MR,Kudo Y,Siriwardena S,et al.Skp2 expression is associated with down-regulation of p27 protein and cell proliferation in salivary adenoid cystic carcinoma[J].Virchows Arch,2007,450(5):567-74.
    [26] Shirasaki T,Maruya S,Mizukami H,et al.Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma[J].BMC Cancer,2008,8:348.
    [27] Shi H, Wang J,Dong F,et al.The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma[J]. BMC Cancer,2009,9:456.
    [28] Hao L,Xiao-lin N,Qi C,et al.Nerve growth factor and vascular endothelial growth factor: retrospective analysis of 63 patients with salivary adenoid cystic carcinoma [J].Int J Oral Sci,2010,2(1):35-44.
  • 期刊类型引用(3)

    1. 李发龙, 孟祥凯, 王忠利, 秦静, 王思钰, 李玉锋, 刘娣. 2023年山东省莒县户籍居民主要恶性肿瘤死亡及减寿分析. 现代医院. 2025(06) 百度学术
    2. 黄芸,陈文俊,朱伟敏,王峰. 2015—2022年克拉玛依市消化系统恶性肿瘤死亡特征与灰色模型预测分析. 疾病预防控制通报. 2024(05): 42-46+56 . 百度学术
    3. 王红英,李胜,明娟,李洁,李元林,杨勇攀,宋启瑞. 2006—2020年中国居民胃癌死亡趋势分析——基于年龄-时期-出生队列模型. 卫生经济研究. 2023(11): 43-48 . 百度学术

    其他类型引用(0)

计量
  • 文章访问数:  1868
  • HTML全文浏览量:  432
  • PDF下载量:  578
  • 被引次数: 3
出版历程
  • 收稿日期:  2013-04-25
  • 修回日期:  2013-07-28
  • 刊出日期:  2014-06-24

目录

    /

    返回文章
    返回
    x 关闭 永久关闭