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泛素特异性蛋白酶2与肿瘤

叶盛威, 魏少忠

叶盛威, 魏少忠. 泛素特异性蛋白酶2与肿瘤[J]. 肿瘤防治研究, 2014, 41(05): 505-508. DOI: 10.3971/j.issn.1000-8578.2014.05.037
引用本文: 叶盛威, 魏少忠. 泛素特异性蛋白酶2与肿瘤[J]. 肿瘤防治研究, 2014, 41(05): 505-508. DOI: 10.3971/j.issn.1000-8578.2014.05.037
YE Shengwei, WEI Shaozhong. Ubiquitin-specific Proteases 2 and Tumour[J]. Cancer Research on Prevention and Treatment, 2014, 41(05): 505-508. DOI: 10.3971/j.issn.1000-8578.2014.05.037
Citation: YE Shengwei, WEI Shaozhong. Ubiquitin-specific Proteases 2 and Tumour[J]. Cancer Research on Prevention and Treatment, 2014, 41(05): 505-508. DOI: 10.3971/j.issn.1000-8578.2014.05.037

泛素特异性蛋白酶2与肿瘤

基金项目: 湖北省自然科学基金资助项目(2012FFB01703);湖北省卫生厅科研基金资助项目(NX2011-14)
详细信息
    作者简介:

    叶盛威(1970-),男,博士,副主任医师,主要从事胃肠肿瘤的研究

  • 中图分类号: R735.3

Ubiquitin-specific Proteases 2 and Tumour

  • 摘要: 泛素特异性蛋白酶2(ubiquitin specifi c protease 2,USP2)基因位于人类染色体11q23.3,转录在5'端不同的切割产生不同的亚型,翻译后产生不同长度的蛋白如USP2a、USP2b和USP2c。USP2是一种重要的去泛素化酶,通过特异性识别靶蛋白,使靶蛋白去泛素化并阻碍其降解,与细胞周期调控、生物钟调节等关系密切。与肿瘤有关的研究中,USP2蛋白的高表达或抑制导致其底物蛋白的含量变化,影响细胞的增殖、成瘤和浸润。在一些培养的细胞系中USP2高表达呈现癌基因特性,可以促进肿瘤的形成,但是在肿瘤坏死因子诱导的促凋亡效应的环节中需要USP2蛋白的参与。出现这些不一致的结果可能与肿瘤中存在不同的同型USP分子和其底物偶联的不同泛素链有关,需要进一步研究。

     

    Abstract: The Ubiquitin-specific protease 2, USP2) gene encodes three different isoforms,USP2a, USP2b and USP2c, due to alternative splicing of the 5' USP2 exons. USP2 is an important deubiquitinating enzyme. It deubiquitinates the target protein and protects it from degradation.It's implicated in the regulation of the cell cycle, circadian, and other biological events. Ectopic expression or inhibition of USP2 causes the accumulation or degradation of its specifi c substrate in a dose-dependent manner, which are implicated in tumor genesis, growth, and progression. High expression of USP2 exhibits oncogenic behavior in cultured cells which may promote tumorigenesis, but it also plays an important role on apoptosis elicited by TNF. The inconsistent results may be related to different isoforms of USP2 and its different ubiquitin chains with substrate protein in tumors. However, further investigation is still needed.

     

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出版历程
  • 收稿日期:  2013-06-26
  • 修回日期:  2013-11-05
  • 刊出日期:  2014-05-24

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