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胃癌中STAT3、p-STAT3和Bcl-xL的表达及临床意义

张竹青, 卢书明, 陈美如, 李春艳, 刘丽娜, 吕 申

张竹青, 卢书明, 陈美如, 李春艳, 刘丽娜, 吕 申. 胃癌中STAT3、p-STAT3和Bcl-xL的表达及临床意义[J]. 肿瘤防治研究, 2014, 41(05): 430-433. DOI: 10.3971/j.issn.1000-8578.2014.05.019
引用本文: 张竹青, 卢书明, 陈美如, 李春艳, 刘丽娜, 吕 申. 胃癌中STAT3、p-STAT3和Bcl-xL的表达及临床意义[J]. 肿瘤防治研究, 2014, 41(05): 430-433. DOI: 10.3971/j.issn.1000-8578.2014.05.019
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ZHANG Zhuqing, LU Shuming, CHEN Meiru, LI Chunyan, LIU Lina, LV Shen. Expressions of STAT3, p-STAT3 and Bcl-xL in Gastric Carcinoma and Their Clinical Signifi cance[J]. Cancer Research on Prevention and Treatment, 2014, 41(05): 430-433. DOI: 10.3971/j.issn.1000-8578.2014.05.019
Citation: ZHANG Zhuqing, LU Shuming, CHEN Meiru, LI Chunyan, LIU Lina, LV Shen. Expressions of STAT3, p-STAT3 and Bcl-xL in Gastric Carcinoma and Their Clinical Signifi cance[J]. Cancer Research on Prevention and Treatment, 2014, 41(05): 430-433. DOI: 10.3971/j.issn.1000-8578.2014.05.019
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胃癌中STAT3、p-STAT3和Bcl-xL的表达及临床意义

  • 1.116033 辽宁大连，大连市中心医院病理科；2.大连医科大学附属第一医院消化内科；3.大连医科大学附属第二医院中心实验室

详细信息
    作者简介:

    张竹青（1978-），女，硕士，主治医师，主要从事胃肠道恶性肿瘤的基础研究

  • 中图分类号: R735.2

Expressions of STAT3, p-STAT3 and Bcl-xL in Gastric Carcinoma and Their Clinical Signifi cance

  • 1.Department of Pathology,Dalian Municipal Central Hospital,Dalian 116033,China;2.Department of Gastroenterology,The First Affi liated Hospital of Dalian Medical University;3.The Central Laboratory,The Second Affi liated Hospital of Dalian Medical University

摘要

    摘要
  • 摘要: 目的 检测STAT3、p-STAT3与其下游靶基因产物Bcl-xL蛋白在胃癌组织中的表达，探讨STAT3 及其靶基因产物在胃癌发病机制中的作用。方法 采用免疫组织化学SP法检测53例胃癌及44例正常胃黏膜组织中STAT3、p-STAT3及Bcl-xL蛋白的表达，并分析其与胃癌临床病理特征的关系。结果 STAT3、p-STAT3及Bcl-xL蛋白在胃癌组织中的阳性表达率显著高于其在正常胃黏膜组织中的阳性表达率，差异均有统计学意义(P均<0.05)。STAT3蛋白的表达与胃癌组织的分化程度及淋巴结转移显著相关（P<0.05）；p-STAT3、Bcl-xL蛋白的表达与胃癌组织的分化程度、浸润深度、有无淋巴结转移及临床分期均有关(P均<0.05)；三者与性别、年龄、肿瘤大小无明显相关性（P均>0.05）。胃癌组织中的p-STAT3与Bcl-xL蛋白表达之间呈正相关（r =0.346，P=0.011）。结论 STAT3信号转导通路在胃癌的发生、发展过程中起重要作用，检测胃癌组织中STAT3及靶基因Bcl-xL的表达有助于判断肿瘤的恶性程度及病情进展。

     

    Abstract: Objective To investigate the expression of signal transducer and activators of transcription 3 (STAT3), p-STAT3 and the downstream transcriptional factor Bcl-xL and their effects in the tumorigenesis and development of gastric carcinoma (GC). Methods The expressions of STAT3, p-STAT3 and Bcl-xL in 53 cases of GC tissues and 44 cases of normal gastric mucosa tissues were assayed by immunohistochemical staining. The correlation of the expression of STAT3, p-STAT3 and Bcl-xL in GC with clinicopathological parameters was analyzed. Results The positive expressions of STAT3, p-STAT3 and Bcl-xL in GC were remarkably higher than those in normal gastric mucosa tissues (all P<0.01 ). STAT3 overexpression was correlated with tumor differentiation and lymph node metastasis (P<0.05), Expressions of p-STAT3 and Bcl-xL were correlated with tumor differentiation, depth of invasion, lymph node metastasis and clinical stage (all P<0.05), while they were not correlated with gender, age or tumor size (all P>0.05). Furthermore, expressions of p-STAT3 and BclxL showed linear positive correlation in GC tissues(r= 0.346,P=0.011). Conclusion STAT3 signaling pathway may play an important role in the tumorigenesis and progression of GC. Determination of STAT3 and its target gene Bcl-xL could be used to indicate the malignancy degree of GC.

     

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出版历程
  • 收稿日期:  2013-05-15
  • 修回日期:  2013-10-22
  • 刊出日期:  2014-05-24

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