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术前吸烟对食管鳞癌患者生存期的影响

郭二涛, 宋 昕, 刘 玉, 彭秀青, 王 苒, 汤 萨, 赵学科, 崔纪丽, 周胜理, 陈 曦, 王立东

郭二涛, 宋 昕, 刘 玉, 彭秀青, 王 苒, 汤 萨, 赵学科, 崔纪丽, 周胜理, 陈 曦, 王立东. 术前吸烟对食管鳞癌患者生存期的影响[J]. 肿瘤防治研究, 2014, 41(03): 231-236. DOI: 10.3971/j.issn.1000-8578.2014.03.008
引用本文: 郭二涛, 宋 昕, 刘 玉, 彭秀青, 王 苒, 汤 萨, 赵学科, 崔纪丽, 周胜理, 陈 曦, 王立东. 术前吸烟对食管鳞癌患者生存期的影响[J]. 肿瘤防治研究, 2014, 41(03): 231-236. DOI: 10.3971/j.issn.1000-8578.2014.03.008
GUO Ertao, SONG Xin, LIU Yu, PENG Xiuqing, WANG Ran, TANG Sa, ZHAO Xueke, CUI Jili, ZHOU Shengli, CHEN Xi, WANG Lidong. Infl uence of Preoperative Smoking on Survival of Patients with Esophageal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(03): 231-236. DOI: 10.3971/j.issn.1000-8578.2014.03.008
Citation: GUO Ertao, SONG Xin, LIU Yu, PENG Xiuqing, WANG Ran, TANG Sa, ZHAO Xueke, CUI Jili, ZHOU Shengli, CHEN Xi, WANG Lidong. Infl uence of Preoperative Smoking on Survival of Patients with Esophageal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(03): 231-236. DOI: 10.3971/j.issn.1000-8578.2014.03.008

术前吸烟对食管鳞癌患者生存期的影响

基金项目: 国家科技部863重大项目(2012AA02A503)
详细信息
    作者简介:

    郭二涛(1985-),男,硕士,主要从事食管和贲门癌变机制与防治研究

    通信作者:

    王立东,E-mail: ldwang2007@126.com

  • 中图分类号: R735.1

Infl uence of Preoperative Smoking on Survival of Patients with Esophageal Squamous Cell Carcinoma

  • 摘要: 目的 探讨术前吸烟对食管鳞癌生存期的影响。方法 通过问卷调查、电话随访和住院病理结果核查。采用t检验和Spearman相关分析吸烟与食管鳞癌发生的关系,Kaplan-Meier生存曲线、Log rank检验、Cox回归评估影响患者生存期的独立因素。结果 吸烟患者平均发病年龄明显高于不吸烟患者(P=0.02),开始吸烟年龄与发病年龄呈正相关(r=0.474,P<0.001);不吸烟患者的生存期优于吸烟患者(P<0.001),然而男性吸烟与不吸烟患者的生存期差异无统计学意义 (P=0.245),并且不吸烟患者中女性患者的生存期明显优于男性(P<0.001);Cox回归分析提示吸烟不是影响食管鳞癌患者生存期的独立因素。结论 食管鳞癌患者发病年龄与开始吸烟年龄高度相关;术前吸烟对食管鳞癌患者的生存期无明显影响。
    Abstract: Objective To investigate the impact of preoperative smoking on survival of the patients with esophageal squamous cell carcinoma (ESCC). Methods Based on the questionnaire, telephone follow-up and hospital pathological records, t-test and Spearman correlation analysis were used to analyze the relationship between smoking and ESCC survival. Kaplan-Meier analysis, Log rank test and Cox regression analysis were applied to analyze the independent risk factors for survival. Results The mean onset age of smoking patients was signifi cantly higher than that of non-smoking patients (P=0.02). The onset age of ESCC was positively correlated with the age of initial smoking (r=0.474,P<0.001). The survival time of non-smoking patients was apparently longer than that of smoking patients (P<0.001). However, there was no difference in male patients no matter smoking status (P=0.245). Moreover, the survival time in non-smoking female patients was signifi cantly longer,compared to non-smoking male (P<0.001). Cox regression analysis showed that preoperative smoking was not the independent factors for ESCC survival. Conclusion The onset age of ESCC patients was highly correlated with the age of initial smoking and preoperative smoking had no impact on the prognosis of ESCC.
  • [1] Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010[J]. CA Cancer J Clin, 2010, 60(5): 277-300.
    [2] Stewart SL,Cardinez CJ,Richardson LC,et al.Surveillance for cancers associated with tobacco use--United States, 1999-2004[J]. MMWR Surveill Summ, 2008, 57(8):1-33.
    [3] Lee YC, Marron M, Benhamou S,et al.Active and involuntary tobacco smoking and upper aerodigestive tract cancer risks in a multicenter case-control study[J].Cancer Epidemiol Biomarkers Prev, 2009, 18(12): 3353-61.
    [4] Liu BQ,Jiang JM,Chen ZM,et al. Relationship between smoking and risk of esophageal cancer in 103 areas in China: a large- scale case-control study incorporated into a nationwide survey of mortality[J]. Zhonghua Yi Xue Za Zhi, 2006, 86(6): 380-5.[刘伯 齐,姜晶梅,陈铮鸣,等. 中国103个地区吸烟与食管癌风险研究: 死因调查中的病例对照方法学研究[J]. 中华医学杂志,2006, 86 (6):380-5.]
    [5] Wang JB, Fan JH, Liang H,et al. Attributable causes of esophageal cancer incidence and mortality in China[J].PLoS One, 2012, 7(8): e42281.
    [6] Sundelöf M,Lagergren J,Ye W.Patient demographics and lifestyle factors infl uencing long-term survival of oesophageal cancer and gastric cardia cancer in a nationwide study in Sweden[J].Eur J Cancer, 2008, 44(11):1566-71.
    [7] Shitara K, Matsuo K, Hatooka S, et al. Heavy smoking history interacts with chemoradiotherapy for esophageal cancer prognosis: a retrospective study[J]. Cancer Sci, 2010, 101(4): 1001-6.
    [8] Trivers KF, De Roos AJ,Gammon MD.Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers[J]. Clin Gastroenterol Hepatol, 2005, 3(3): 225-30.
    [9] Bohanes P, Yang D, Chhibar RS, et al. Influence of sex on the survival of patients with esophageal cancer[J]. J Clin Oncol, 2012, 30 (18):2265-72.
    [10] Ueo H,Matsuoka H,Sugimachi K,et al.Inhibitory effects of estrogen on the growth of a human esophageal carcinoma cell line[J].Cancer Res, 1990,50(22):7212-5.
    [11] Yamashita Y,Hirai T,Mukaida H,et al.Detection of androgen receptors in human esophageal cancer[J]. Jpn J Surg, 1989, 19 (2):195-202.
    [12] Gao YT, McLaugulin JK, Blot WJ, et al. Risk factors for esophageal cancer in Shanghai, China. I. Role of cigarette smoking and alcohol drinking[J]. Int J Cancer, 1994, 58(2): 192-6.
    [13] Cheng KK, Day NE, Duffy SW, et al. Picked vegetables in the aetiology of oesophageal cancer in Hong Kong Chinese [J]. Lancet, 1992, 339(8805): 1314-8.
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出版历程
  • 收稿日期:  2013-08-18
  • 修回日期:  2013-10-20
  • 刊出日期:  2014-03-24

目录

    Corresponding author: WANG Lidong, ldwang2007@126.com

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