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[1] Cohen-Fix O. Cell biology: Import and nuclear size[J]. Nature, 2010, 468(7323):513-6. [2] Turner JG, Dawson J, Sullivan DM. Nuclear export of proteins and drug resistance in cancer[J]. Biochem Pharmacol, 2012,83(8): 1021-32. [3] Gasiorowski JZ,Dean DA. Mechanisms of nuclear transport and interventions[J]. Adv Drug Deliv Rev, 2003,55 (6):703-16. [4] Antoine M, Reimers K, Wirz W, et al. Identification of an unconventional nuclear localization signal in human ribosomal protein S2[J].Biochem Biophys Res Commun,2005, 335(1):146-53. [5] Lee BJ, Cansizoglu AE, Süel KE, et al. Rules for nuclear localization sequence recognition by karyopherin beta 2[J]. Cell, 2006, 126(3):543-58. [6] Kotera I, Sekimoto T, Miyamoto Y,et al. Importin alpha transports CaMKIV to the nucleus without utilizing importin beta[J]. EMBO J, 2005, 24(5):942-51. [7] Nakielny S, Dreyfuss G. Import and export of the nuclear protein import receptor transportin by a mechanism independent of GTP hydrolysis[J]. Curr Biol, 1998, 8(2):89-95. [8] Fagotto F,Gluck U,Gumbiner BM.Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin[J].Curr Biol,1998, 8(4):181-90. [9] Sachdev S, Bagchi S, Zhang DD, et al. Nuclear import of IkappaBalpha is accomplished by a ran-independent transport pathway[J]. Mol Cell Biol, 2000, 20(5):1571-82. [10] Terry LJ, Shows EB, Wente SR. Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport[J]. Science, 2007, 318(5855):1412-6. [11] Rosin-Arbesfeld R, Cliffe A, Brabletz T, et al. Nuclear export of the APC tumor suppressor controls beta-catenin function in transcription[J]. EMBO J, 2003, 22(5):1101-13. [12] O'Brate A, Giannakakou P. The importance of p53 location: nuclear or cytoplasmic zip code[J]. Drug Resist Updat, 2003, 6(6):313-22. [13] Rodriguez JA, Henderson BR. Identification of a functional nuclear export sequence in BRCA1[J]. J Biol Chem, 2000, 275(49):38589-96. [14] Santos A, Calvet L, Terrier-Lacombe MJ, et al. In vivo treatment with CPT-11 leads to differentiation of neuroblastoma xenografts and topoisomerase I alterations[J].Cancer Res, 2004, 64(9):3223-9. [15] Oloumi A, MacPhail SH, Johnston PJ, et al. Changes in subcellular distribution of topoisomerase II alpha correlate with etoposide resistance in multicell spheroids and xenograft tumors[J]. Cancer Res, 2000, 60(20):5747-53. [16] Vogt PK, Jiang H, Aoki M. Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins[J]. Cell Cycle, 2005, 4(7):908-13. [17] Aloisi A, Di Gregorio S, Stagno F, et al. BCR-ABL nuclear entrapment kills human CML cells: ex vivo study on 35 patients with the combination of imatinib mesylate and leptomycin B[J]. Blood, 2006, 107(4):1591-8. [18] Diehl MC, Idowu MO, Kimmelshue K, et al. Elevated expression of nuclear Hsp90 in invasive breast tumors[J]. Cancer Biol Ther, 2009, 8(20):1952-61. [19] van der Watt PJ, Maske CP, Hendricks DT, et al. The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation[J]. Int J Cancer, 2009, 124(8):1829-40. [20] Engel R, Valkov NI, Gump JL, et al. The cytoplasmic trafficking of DNA topoisomerase IIalpha correlates with etoposide resistance in human myeloma cells[J]. Exp Cell Res, 2004, 295(2):421-31. [21] Takenaka Y, Fukumori T, Yoshii T, et al. Nuclear export of phosphorylated galectin-3 regulates its antiapoptotic activity in response to chemotherapeutic drugs[J]. Mol Cell Biol, 2004, 24(10):4395-406. [22] Demchenko YN, Kuehl WM. A critical role for the NFkB pathway in multiple myeloma[J]. Oncotarget, 2010, 1(1):59-68. [23] Rhee YH, Jeong SJ, Lee HJ, et al. Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells[J]. BMC Cancer, 2012, 12:28. [24] Cimica V, Chen HC, Iyer JK, et al. Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin- beta1[J]. PLoS One, 2011, 6(5):e20188. [25] Leithner K, Stacher E, Wurm R, et al. Nuclear and cytoplasmic death receptor 5 as prognostic factors in patients with non-small cell lung cancer treated with chemotherapy[J]. Lung Cancer, 2009, 65(1):98-104. [26] Kojima Y, Nakayama M, Nishina T, et al. Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells[J]. J Biol Chem,2011, 286(50):43383-93. [27] Newlands ES, Rustin GJ, Brampton MH. Phase I trial of elactocin[J]. Br J Cancer, 1996, 74(4):648-9. [28] Mutka SC, Yang WQ, Dong SD, et al. Identification of nuclear export inhibitors with potent anticancer activity in vivo[J]. Cancer Res, 2009, 69(2):510-7. [29] Sakakibara K, Saito N, Sato T, et al. CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity[J]. Blood, 2011, 118(14):3922-31. [30] Draetta GF, Shacham S, Kauffman M, et al. Cytotoxicity of novel, small molecule, CRM1-selective inhibitors of nuclear export (SINE) in colorectal cancer (CRC) cells[J]. J Clin Oncol, 2011, 29: e14091[Abstract]. [31] Hintersteiner M, Ambrus G, Bednenko J, et al. Identification of a small molecule inhibitor of importin beta mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries[J]. ACS Chem Biol, 2010, 5(10):967-79. [32] Ambrus G, Whitby LR, Singer EL, et al. Small molecule peptidomimetic inhibitors of importin alpha/beta mediated nuclear transport[J]. Bioorg Med Chem, 2010, 18(21):7611-20. [33] Soderholm JF, Bird SL, Kalab P, et al. Importazole, a small molecule inhibitor of the transport receptor importin-beta[J]. ACS Chem Biol, 2011, 6(7):700-8. [34] Wagstaff KM, Sivakumaran H, Heaton SM, et al. Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus[J]. Biochem J, 2012, 443(3):851-6.
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