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新疆哈萨克族食管鳞癌中HLA-G的表达及临床意义

刘杨正, 胡建明, 李锋, 李玲, 闫小龙, 李 鑫, 陈文娟, 熊洋洋

刘杨正, 胡建明, 李锋, 李玲, 闫小龙, 李 鑫, 陈文娟, 熊洋洋. 新疆哈萨克族食管鳞癌中HLA-G的表达及临床意义[J]. 肿瘤防治研究, 2013, 40(02): 164-167. DOI: 10.3971/j.issn.1000-8578.2013.02.010
引用本文: 刘杨正, 胡建明, 李锋, 李玲, 闫小龙, 李 鑫, 陈文娟, 熊洋洋. 新疆哈萨克族食管鳞癌中HLA-G的表达及临床意义[J]. 肿瘤防治研究, 2013, 40(02): 164-167. DOI: 10.3971/j.issn.1000-8578.2013.02.010
Liu Yangzheng, Hu Jianming, Li Feng, Li Ling, Yan Xiaolong, Li Xin, Chen Wenjuan, Xiong Yangyang. Expression and Significance of HLA-G in Kazak Patients with Esophageal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2013, 40(02): 164-167. DOI: 10.3971/j.issn.1000-8578.2013.02.010
Citation: Liu Yangzheng, Hu Jianming, Li Feng, Li Ling, Yan Xiaolong, Li Xin, Chen Wenjuan, Xiong Yangyang. Expression and Significance of HLA-G in Kazak Patients with Esophageal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2013, 40(02): 164-167. DOI: 10.3971/j.issn.1000-8578.2013.02.010

新疆哈萨克族食管鳞癌中HLA-G的表达及临床意义

详细信息
    作者简介:

    刘杨正(1990-),男,本科在读,主要从事肿瘤流行病学研究

    通信作者:

    胡建明,E-mail:jianming120@yahoo.com.cn

  • 中图分类号: R735.1

Expression and Significance of HLA-G in Kazak Patients with Esophageal Squamous Cell Carcinoma

  • 摘要: 目的 探讨人类白细胞抗原-G(human leucocyte antigen,HLA-G)在新疆哈萨克族食管鳞癌中的表达及临床意义。 方法应用免疫组织化学SP 法对30例哈族食管鳞癌及20例癌旁正常组织中HLA-G 的表达进行检测。结果哈族食管鳞癌组织中HLA-G的表达率为66.7%,明显高于癌旁正常组织20.0%,差异具有统计学意义(P<0.05);HLA-G的表达与哈族食管癌浸润深度和临床分期关系密切(P均<0.05),而与患者年龄、性别、食管癌发生部位、分化程度和淋巴结转移无明显相关性(P均>0.05)。结论HLA-G的高表达可能在新疆哈族食管鳞癌的发生发展中起重要作用。
    Abstract: Objective To investigate the expression and clinical significance of HLA-G in Xinjiang Kazak patients with esophageal squamous cell carcinoma(ESCC). Methods The expression of HLA-G was detected using SP immunohistochemical staining in 30 ESCC and 20 cases of tumor adjacent normal tissues. Results The positive rate of HLA-G expression in ESCC was 66.7%(20/30),significantly higher than that in tumor adjacent normal tissues(20%)(P<0.05).The positive rate of HLA-G was closely related with depth of invasion and clinical stage(P<0.05 for all),but not with age,gender,tumor location,histologic grade and lymphnode metastasis(P>0.05 for all). Conclusion The significantly over expression of HLA-G might play a key role in the pathogenesis of Kazak ESCC in Kazak population.
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出版历程
  • 收稿日期:  2012-03-14
  • 修回日期:  2012-06-26
  • 刊出日期:  2013-02-24

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    Xiong Yangyang

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