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ZHAO Yuqiao, LIU Guanglin, WANG Haicun, GAO Xin, JIANG Xingming, LIU Lang. Influence of LncRNA NKILA on Biological Behavior of Malignant Tumors and Related Mechanism[J]. Cancer Research on Prevention and Treatment, 2022, 49(1): 67-71. DOI: 10.3971/j.issn.1000-8578.2022.21.0792
Citation: ZHAO Yuqiao, LIU Guanglin, WANG Haicun, GAO Xin, JIANG Xingming, LIU Lang. Influence of LncRNA NKILA on Biological Behavior of Malignant Tumors and Related Mechanism[J]. Cancer Research on Prevention and Treatment, 2022, 49(1): 67-71. DOI: 10.3971/j.issn.1000-8578.2022.21.0792

Influence of LncRNA NKILA on Biological Behavior of Malignant Tumors and Related Mechanism

Funding: 

National Natural Science Foundation of China 81602088

National Natural Science Foundation of Heilongjiang Province LH2020H058

Chen Xiaoping Foundation for the Development of Science and Technology of Hubei Province CXPJJH12000002-2020015

More Information
  • Corresponding author:

    JIANG Xingming, E-mail: xmjiang@hrbmu.edu.cn

  • Received Date: July 06, 2021
  • Revised Date: October 21, 2021
  • Available Online: January 12, 2024
  • NKILA is a kind of newly-discovered lncRNA whose expression is aberrant in diverse malignant tumors. The existing researches have confirmed that NKILA participates in the occurrence and development of tumors mainly by regulating the NF-κB signaling pathway, and has significance to the cancer diagnosis, treatment and prognostic evaluation of patients. This article reviews the abnormal expressions and biological effects of NKILA, and the up- and down-stream mechanisms of NKILA regulating malignant biological behavior in different cancers.

  • [1]
    Mattick JS. Non-coding RNAs: the architects of eukaryotic complexity[J]. EMBO Rep, 2001, 2(11): 986-991. doi: 10.1093/embo-reports/kve230
    [2]
    王微娜, 毕永红, 张瑞芹, 等. 消化系统恶性肿瘤中BANCR的表达及调控作用研究[J]. 肿瘤学杂志, 2020, 26(2): 145-149. https://www.cnki.com.cn/Article/CJFDTOTAL-XHON202002014.htm

    Wang WN, Bi YH, Zhang RQ, et al. Expression and Regulatory Effects of BANCR in Digestive System Malignancies[J]. Zhong Liu Xue Za Zhi, 2020, 26(2): 145-149. https://www.cnki.com.cn/Article/CJFDTOTAL-XHON202002014.htm
    [3]
    栗浩然, 王雅莉, 李红娟, 等. lncRNA FAL1通过调控MAPK通路对卵巢癌细胞化疗耐药性的影响及其机制[J]. 肿瘤防治研究, 2021, 48(4): 333-340. doi: 10.3971/j.issn.1000-8578.2021.20.0752

    Li HR, Wang YL, Li HJ, et al. Effect of lncRNA FAL1 on Chemotherapy Resistance of Ovarian Cancer Cells by Regulating MAPK Pathway and Related Mechanism[J]. Zhong Liu Fang Zhi Yan Jiu, 2021, 48(4): 333-340. doi: 10.3971/j.issn.1000-8578.2021.20.0752
    [4]
    Xue H, Yu P, Wang WZ, et al. The reduced lncRNA NKILA inhibited proliferation and promoted apoptosis of chondrocytes via miR-145/SP1/NF-κB signaling in human osteoarthritis[J]. Eur Rev Med Pharmacol Sci, 2020, 24(2): 535-548.
    [5]
    Li QY, Li PR, Su JL, et al. LncRNA NKILA was upregulated in diabetic cardiomyopathy with early prediction values[J]. Exp Ther Med, 2019, 18(2): 1221-1225. https://www.ncbi.nlm.nih.gov/pubmed/31316617
    [6]
    Yang YM, Li YH, Ding LL, et al. Regulatory effect of lncRNA NKILA on autophagy induced by sepsis kidney injury[J]. Eur Rev Med Pharmacol Sci, 2020, 24(8): 4057. https://pubmed.ncbi.nlm.nih.gov/31599426/
    [7]
    Liu Q, Liu Z, Zhou LJ, et al. The long noncoding RNA NKILA protects against myocardial ischaemic injury by enhancing myocardin expression via suppressing the NF-κB signalling pathway[J]. Exp Cell Res, 2020, 387(2): 111774. doi: 10.1016/j.yexcr.2019.111774
    [8]
    Liu BD, Sun LJ, Liu Q, et al. A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis[J]. Cancer Cell, 2015, 27(3): 370-381. doi: 10.1016/j.ccell.2015.02.004
    [9]
    Luo LH, Rao L, Luo LF, et al. Long non-coding RNA NKILA inhibited angiogenesis of breast cancer through NF-κB/IL-6 signaling pathway[J]. Microvasc Res, 2020, 129: 103968. doi: 10.1016/j.mvr.2019.103968
    [10]
    Li DM, Zhong M, Su QB, et al. Active fraction of Polyrhachisvicina Rogers (AFPR) suppressed breast cancer growth and progression via regulating EGR1/lncRNA-NKILA/NF-κB axis[J]. Biomed Pharmacother, 2020, 123: 109616. doi: 10.1016/j.biopha.2019.109616
    [11]
    Duan SZ, Chan WK, Oman A, et al. NF-κB/NKILA signaling modulates the anti-cancerous effects of EZH2 inhibition[J]. J Cell Mol Med, 2019, 23(9): 6182-6192. doi: 10.1111/jcmm.14500
    [12]
    Wu W, Chen F, Cui XY, et al. LncRNA NKILA suppresses TGF-β-induced epithelial-mesenchymal transition by blocking NF-κB signaling in breast cancer[J]. Int J Cancer, 2018, 143(9): 2213-2224. doi: 10.1002/ijc.31605
    [13]
    Tibatan MA, ÖnayUçar E. Long non-coding RNA NKILA regulates expression of HSP90α, NF-κB and β-catenin proteins in the MCF-7 breast cancer cell line[J]. Mol Biol Rep, 2021, 48(5): 4563-4571. doi: 10.1007/s11033-021-06482-y
    [14]
    Wang FP, Jiang XC, Wang P. NF-κB interaction long non-coding RNA inhibits migration, invasion and epithelial-mesenchymal transition of cervical cancer cells through inhibiting NF-κB signaling pathways[J]. Exp Ther Med, 2020, 20(2): 1039-1047. doi: 10.3892/etm.2020.8752
    [15]
    Wang J, Zhu Z, Qiu H, et al. LncRNA NKILA inhibits the proliferation and promotes the apoptosis of CSCC cells by downregulating miRNA-21[J]. J Cell Physiol, 2020, 235(11): 7863-7869. doi: 10.1002/jcp.29439
    [16]
    宁佳羽, 包伟晶, 周素娟, 等. LncRNA-MEG3和KLF4在鼻咽癌发生发展中的作用及可能机制[J]. 肿瘤防治研究, 2021, 48(3): 234-238. doi: 10.3971/j.issn.1000-8578.2021.20.0790

    Ning JY, Bao WJ, Zhou SJ, et al. Role and Possible Mechanism of LncRNA-MEG3 and KLF4 in Carcinogenesis and Progression of Nasopharyngeal Carcinoma[J]. Zhong Liu Fang Zhi Yan Jiu, 2021, 48(3): 234-238. doi: 10.3971/j.issn.1000-8578.2021.20.0790
    [17]
    Zhang W, Guo QN, Liu GY, et al. NKILA represses nasopharyngeal carcinoma carcinogenesis and metastasis by NF-κB pathway inhibition[J]. PLoS Genet, 2019, 15(8): e1008325. doi: 10.1371/journal.pgen.1008325
    [18]
    Yang T, Li SS, Liu JJ, et al. lncRNA-NKILA/NF-κB feedback loop modulates laryngeal cancer cell proliferation, invasion, and radioresistance[J]. Cancer Med, 2018, 7(5): 2048-2063. doi: 10.1002/cam4.1405
    [19]
    席婕, 戴皓, 刘晖, 等. lncRNA-NKILA靶向NF-κB调控喉癌细胞的增殖和侵袭[J]. 医学分子生物学杂志, 2018, 15(6): 379-383. doi: 10.3870/j.issn.1672-8009.2018.06.004

    Xi J, Dai H, Liu H, et al. LncRNA-NKILA Targets NF-κB Regulates Proliferation and Invasion of Laryngeal Carcinoma Cells[J]. Yi Xue Fen Zi Sheng Wu Xue Za Zhi, 2018, 15(6): 379-383. doi: 10.3870/j.issn.1672-8009.2018.06.004
    [20]
    Lu ZL, Li Y, Wang JN, et al. Long non-coding RNA NKILA inhibits migration and invasion of non-small cell lung cancer via NF-κB/Snail pathway[J]. J Exp Clin Cancer Res, 2017, 36(1): 54. doi: 10.1186/s13046-017-0518-0
    [21]
    Liu DM, Shi XY. Long non-coding RNA NKILA inhibits proliferation and migration of lung cancer via IL-11/STAT3 signaling[J]. Int J Clin Exp Pathol, 2019, 12(7): 2595-2603. https://www.ncbi.nlm.nih.gov/pubmed/31934087
    [22]
    胡增涛, 王微娜, 孙东升, 等. 食管鳞状细胞癌中环状RNA的生物学功能与调控机制研究[J]. 临床误诊误治, 2020, 33(3): 121-124. doi: 10.3969/j.issn.1002-3429.2020.03.027

    Hu ZT, Wang WN, Sun DS, et al. Research on the biological function and regulatory mechanism of cyclic RNA in esophageal squamous cell carcinoma[J]. Lin Chuang Wu Zhen Wu Zhi, 2020, 33(3): 121-124. doi: 10.3969/j.issn.1002-3429.2020.03.027
    [23]
    Lu ZL, Chen ZL, Li Y, et al. TGF-β-induced NKILA inhibits ESCC cell migration and invasion through NF-κB/MMP14 signaling[J]. J Mol Med (Berl), 2018, 96(3-4): 301-313. doi: 10.1007/s00109-018-1621-1
    [24]
    Ke S, Li RC, Meng FK, et al. NKILA inhibits NF-κB signaling and suppresses tumor metastasis[J]. Aging (Albany NY), 2018, 10(1): 56-71. https://pubmed.ncbi.nlm.nih.gov/29348395/
    [25]
    Tao F, Xu YP, Yang DZ, et al. LncRNA NKILA correlates with the malignant status and serves as a tumor-suppressive role in rectal cancer[J]. J Cell Biochem, 2018, 119(12): 9809-9816. doi: 10.1002/jcb.27300
    [26]
    Jiang P, Han XT, Zheng YN, et al. Long non-coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer[J]. Oncol Lett, 2019, 18(2): 2109-2117. https://pubmed.ncbi.nlm.nih.gov/31423284/
    [27]
    Chen RG, Cheng QY, Owusu-Ansah KG, et al. NKILA, a prognostic indicator, inhibits tumor metastasis by suppressing NF-κB/Slug mediated epithelial-mesenchymal transition in hepatocellular carcinoma[J]. Int J Biol Sci, 2020, 16(3): 495-503. doi: 10.7150/ijbs.39582
    [28]
    Yu XL, Tang W, Yang YC, et al. Long noncoding RNA NKILA enhances the anti-cancer effects of baicalein in hepatocellular carcinoma via the regulation of NF-κB signaling[J]. Chem Biol Interact, 2018, 285: 48-58. doi: 10.1016/j.cbi.2018.02.027
    [29]
    Zhang GD, Li Y, Liao GJ, et al. LncRNA NKILA inhibits invasion and migration of osteosarcoma cells via NF-κB/Snail signaling pathway[J]. Eur Rev Med Pharmacol Sci, 2019, 23(10): 4118-4125. https://pubmed.ncbi.nlm.nih.gov/31173281/
    [30]
    Bian DH, Gao C, Bao K, et al. The long non-coding RNA NKILA inhibits the invasion-metastasis cascade of malignant melanoma via the regulation of NF-κB[J]. Am J Cancer Res, 2017, 7(1): 28-40. https://pubmed.ncbi.nlm.nih.gov/28123845/
    [31]
    Lyu XM, Ma YQ, Wu F, et al. LncRNA NKILA inhibits retinoblastoma by downregulating lncRNA XIST[J]. Curr Eye Res, 2019, 44(9): 975-979. doi: 10.1080/02713683.2019.1606253
    [32]
    Huang W, Cui XY, Chen JN, et al. Long non-coding RNA NKILA inhibits migration and invasion of tongue squamous cell carcinoma cells via suppressing epithelial-mesenchymal transition[J]. Oncotarget, 2016, 7(38): 62520-62532. doi: 10.18632/oncotarget.11528
    [33]
    Hu DY, Zhong T, Dai Q. Long Non-Coding RNA NKILA Reduces Oral Squamous Cell Carcinoma Development Through the NF-KappaB Signaling Pathway[J]. Technol Cancer Res Treat, 2020, 19: 1533033820960747. https://pubmed.ncbi.nlm.nih.gov/33143574/
    [34]
    Chen Z, Li ST, Shen L, et al. NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas[J]. Cell Death Dis, 2020, 11(5): 323. doi: 10.1038/s41419-020-2520-2

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