Relation Between Tumor Budding and Endoscopic Classification, Degree of Malignancy in T1 Stage Esophageal Squamous Cell Carcinoma

WANG Kang; YANG Chun

doi:10.3971/j.issn.1000-8578.2021.21.0262

Cancer Research on Prevention and Treatment > 2021 > 48(10): 952-957. > DOI: 10.3971/j.issn.1000-8578.2021.21.0262

WANG Kang, YANG Chun. Relation Between Tumor Budding and Endoscopic Classification, Degree of Malignancy in T1 Stage Esophageal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2021, 48(10): 952-957. DOI: 10.3971/j.issn.1000-8578.2021.21.0262

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Relation Between Tumor Budding and Endoscopic Classification, Degree of Malignancy in T1 Stage Esophageal Squamous Cell Carcinoma

WANG Kang¹,
YANG Chun^2, ,

1.
Department of Pathology, Nanjing Hospital of Traditional Chinese Medicine, Nanjing 210000, China
2.
Department of Gastroenterology, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing 211102, China

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Corresponding author:
YANG Chun, E-mail: 2504576454@qq.com
Received Date: March 10, 2021
Revised Date: July 24, 2021
Available Online: January 12, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the clinical pathological significance of tumor budding in T1 stage esophageal squamous cell carcinoma.
Methods
Tumor budding was searched for in the resected tissues of T1 stage esophageal squamous cell carcinoma(ESCC), and the relation between tumor budding and endoscopic classification, degree of malignancy in T1 ESCC were analyzed.
Results
The detection rate of tumor budding was significantly improved after EGFR labeling(P < 0.05). The detection rate of tumor budding in T1b ESCC was significantly higher than that of T1a SCC(P < 0.05). The detection rate of tumor budding in the cases with lymph node metastasis was significantly higher than that without lymph node metastasis(P < 0.05). The detection rate of tumor budding in stage ⅡB ESCC was significantly higher than those with stageⅠB(P < 0.05).
Conclusion
The detection rate of tumor budding in T1 ESCC is relatively high. The detection rates of tumor budding is improved by EGFR immunohistochemistrical labeling. The occurrence of tumor budding in T1 ESCC indicates more tumor aggression.
- Tumor budding,
- Esophageal squamous cell carcinoma,
- Endoscopic classification,
- EGFR

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References (21)

References

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Relation Between Tumor Budding and Endoscopic Classification, Degree of Malignancy in T1 Stage Esophageal Squamous Cell Carcinoma