| Citation: |
JIN Ruizhe, WANG Dixian, ZHAO Qian, LIU Tiejun. miR-155-5p Expression, Function and Regulation in Tumors[J]. Cancer Research on Prevention and Treatment, 2023, 50(3): 309-315. DOI: 10.3971/j.issn.1000-8578.2023.22.1026
|
MicroRNAs (miRNAs) are a class of small, single-stranded non-coding RNAs that act as important regulators of gene expression and are involved in a number of important processes in life. A large number of studies have suggested that dysregulation of miRNA expression may be an important part of the mechanism of human tumorigenesis and progression. MiR-155-5p is mainly regarded as an oncomiR that acts on multiple target genes to participate in tumor progression, although it has been suggested to possess cancer growth suppressor effects. In this paper, we summarize the effects of miR-155-5p on cancer cell proliferation, invasion, migration, and drug resistance in various tumor types and elucidate its value as a possible potential marker in assisting diagnosis.
Competing interests: The authors declare that they have no competing interests.
| [1] |
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. doi: 10.3322/caac.21660
|
| [2] |
D'souza W, Kumar A. microRNAs in oral cancer: Moving from bench to bed as next generation medicine[J]. Oral Oncol, 2020, 111: 104916. doi: 10.1016/j.oraloncology.2020.104916
|
| [3] |
Papageorgiou SG, Kontos CK, Diamantopoulos MA, et al. MicroRNA-155-5p Overexpression in Peripheral Blood Mononuclear Cells of Chronic Lymphocytic Leukemia Patients Is a Novel, Independent Molecular Biomarker of Poor Prognosis[J]. Dis Markers, 2017, 2017: 2046545.
|
| [4] |
Metzler M, Wilda M, Busch K, et al. High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma[J]. Genes Chromosomes Cancer, 2004, 39(2): 167-169. doi: 10.1002/gcc.10316
|
| [5] |
Elton TS, Selemon H, Elton SM, et al. Regulation of the MIR155 host gene in physiological and pathological processes[J]. Gene, 2013, 532(1): 1-12. doi: 10.1016/j.gene.2012.12.009
|
| [6] |
Merkerova M, Belickova M, Bruchova H. Differential expression of microRNAs in hematopoietic cell lineages[J]. Eur J Haematol, 2008, 81(4): 304-310. doi: 10.1111/j.1600-0609.2008.01111.x
|
| [7] |
Zhang J, Zhu L, Shi H, et al. Protective effects of miR-155-5p silencing on IFN-gamma-induced apoptosis and inflammation in salivary gland epithelial cells[J]. Exp Ther Med, 2021, 22(2): 882. doi: 10.3892/etm.2021.10314
|
| [8] |
Chen A, Wen J, Lu C, et al. Inhibition of miR1555p attenuates the valvular damage induced by rheumatic heart disease[J]. Int J Mol Med, 2020, 45(2): 429-440.
|
| [9] |
Wang X, Bustos MA, Zhang X, et al. Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-kappaB1 Target SerpinE1 in Aggressive Glioblastoma Tumors[J]. Cancers (Basel), 2020, 12(5): 1081. doi: 10.3390/cancers12051081
|
| [10] |
Gao Y, Ma X, Yao Y, et al. miR-155 regulates the proliferation and invasion of clear cell renal cell carcinoma cells by targeting E2F2[J]. Oncotarget, 2016, 7(15): 20324-20337. doi: 10.18632/oncotarget.7951
|
| [11] |
Bhattacharya S, Chalk AM, Ng AJ, et al. Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death[J]. Oncogene, 2016, 35(40): 5282-5294. doi: 10.1038/onc.2016.68
|
| [12] |
Sun X, Geng X, Zhang J, et al. miR-155 promotes the growth of osteosarcoma in a HBP1-dependent mechanism[J]. Mol Cell Biochem, 2015, 403(1-2): 139-147. doi: 10.1007/s11010-015-2344-z
|
| [13] |
Fu X, Wen H, Jing L, et al. MicroRNA-155-5p promotes hepatocellular carcinoma progression by suppressing PTEN through the PI3K/Akt pathway[J]. Cancer Sci, 2017, 108(4): 620-631. doi: 10.1111/cas.13177
|
| [14] |
Liu W, Zhou X, Li Y, et al. Long Non-Coding RNA NORAD Inhibits Breast Cancer Cell Proliferation and Metastasis by Regulating miR-155-5p/SOCS1 Axis[J]. J Breast Cancer, 2021, 24(3): 330-343. doi: 10.4048/jbc.2021.24.e32
|
| [15] |
Li X, Chen Z, Ni Y, et al. Tumor-associated macrophages secret exosomal miR-155 and miR-196a-5p to promote metastasis of non-small-cell lung cancer[J]. Transl Lung Cancer Res, 2021, 10(3): 1338-1354. doi: 10.21037/tlcr-20-1255
|
| [16] |
Zhang J, Ye Y, Chang DW, et al. Global and Targeted miRNA Expression Profiling in Clear Cell Renal Cell Carcinoma Tissues Potentially Links miR-155-5p and miR-210-3p to both Tumorigenesis and Recurrence[J]. Am J Pathol, 2018, 188(11): 2487-2496. doi: 10.1016/j.ajpath.2018.07.026
|
| [17] |
Zheng Z, Sun R, Zhao HJ, et al. MiR155 sensitized B-lymphoma cells to anti-PD-L1 antibody via PD-1/PD-L1-mediated lymphoma cell interaction with CD8+T cells[J]. Mol Cancer, 2019, 18(1): 54. doi: 10.1186/s12943-019-0977-3
|
| [18] |
Wang D, Wang X, Song Y, et al. Exosomal miR-146a-5p and miR-155-5p promote CXCL12/CXCR7-induced metastasis of colorectal cancer by crosstalk with cancer-associated fibroblasts[J]. Cell Death Dis, 2022, 13(4): 380. doi: 10.1038/s41419-022-04825-6
|
| [19] |
Lei QQ, Huang Y, Li B, et al. MiR-155-5p promotes metastasis and epithelial-mesenchymal transition of renal cell carcinoma by targeting apoptosis-inducing factor[J]. Int J Biol Markers, 2021, 36(1): 20-27. doi: 10.1177/1724600820978229
|
| [20] |
Baba O, Hasegawa S, Nagai H, et al. MicroRNA-155-5p is associated with oral squamous cell carcinoma metastasis and poor prognosis[J]. J Oral Pathol Med, 2016, 45(4): 248-255. doi: 10.1111/jop.12351
|
| [21] |
Han X, Liu J, Liu Y, et al. LINC-PINT Inhibited Malignant Progression of Bladder Cancer by Targeting miR-155-5p[J]. Cancer Manag Res, 2021, 13: 4393-4401. doi: 10.2147/CMAR.S305547
|
| [22] |
Kong W, He L, Richards EJ, et al. Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer[J]. Oncogene, 2014, 33(6): 679-689. doi: 10.1038/onc.2012.636
|
| [23] |
Zhou X, Yan T, Huang C, et al. Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway[J]. J Exp Clin Cancer Res, 2018, 37(1): 242. doi: 10.1186/s13046-018-0911-3
|
| [24] |
Yang Y, Guo Z, Chen W, et al. M2 Macrophage-Derived Exosomes Promote Angiogenesis and Growth of Pancreatic Ductal Adenocarcinoma by Targeting E2F2[J]. Mol Ther, 2021, 29(3): 1226-1238. doi: 10.1016/j.ymthe.2020.11.024
|
| [25] |
Wang L, Tang B, Han H, et al. miR-155 Affects Osteosarcoma MG-63 Cell Autophagy Induced by Adriamycin Through Regulating PTEN-PI3K/AKT/mTOR Signaling Pathway[J]. Cancer Biother Radiopharm, 2018, 33(1): 32-38.
|
| [26] |
Xu W, Song C, Wang X, et al. Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis[J]. Aging (Albany NY), 2021, 13(1): 228-240.
|
| [27] |
Wang M, Qiu R, Yu S, et al. Paclitaxelresistant gastric cancer MGC803 cells promote epithelialtomesenchymal transition and chemoresistance in paclitaxel-sensitive cells via exosomal delivery of miR1555p[J]. Int J Oncol, 2019, 54(1): 326-338.
|
| [28] |
Luo W, Zhang H, Liang X, et al. DNA methylation-regulated miR1555p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10[J]. Oncol Rep, 2020, 43(5): 1692-1704.
|
| [29] |
Yu Q, Xu XP, Yin XM, et al. miR-155-5p increases the sensitivity of liver cancer cells to adriamycin by regulating ATG5-mediated autophagy[J]. Neoplasma, 2021, 68(1): 87-95. doi: 10.4149/neo_2020_200106N17
|
| [30] |
Wang Y, Zhou B, Yan L, et al. lncRNA NORAD promotes the progression of osteosarcoma via targeting of miR-155-5p[J]. Exp Ther Med, 2021, 21(6): 645. doi: 10.3892/etm.2021.10077
|
| [31] |
Liu F, Mao Q, Zhu S, et al. MicroRNA-155-5p promotes cell proliferation and invasion in lung squamous cell carcinoma through negative regulation of fibroblast growth factor 9 expression[J]. J Thorac Dis, 2021, 13(6): 3669-3679. doi: 10.21037/jtd-21-882
|
| [32] |
Lin J, Chen Y, Liu L, et al. MicroRNA-155-5p suppresses the migration and invasion of lung adenocarcinoma A549 cells by targeting Smad2[J]. Oncol Lett, 2018, 16(2): 2444-2452.
|
| [33] |
Wang F, Shan S, Huo Y, et al. MiR-155-5p inhibits PDK1 and promotes autophagy via the mTOR pathway in cervical cancer[J]. Int J Biochem Cell Biol, 2018, 99: 91-99. doi: 10.1016/j.biocel.2018.04.005
|
| [34] |
Swellam M, Zahran RFK, Abo El-Sadat Taha H, et al. Role of some circulating MiRNAs on breast cancer diagnosis[J]. Arch Physiol Biochem, 2019, 125(5): 456-464. doi: 10.1080/13813455.2018.1482355
|
| [35] |
Kim H, Yang JM, Ahn SH, et al. Potential Oncogenic Role and Prognostic Implication of MicroRNA-155-5p in Oral Squamous Cell Carcinoma[J]. Anticancer Res, 2018, 38(9): 5193-5200. doi: 10.21873/anticanres.12842
|
| [36] |
Li Y, Zhang Y, Zhang S, et al. circRNA circARNT2 Suppressed the Sensitivity of Hepatocellular Carcinoma Cells to Cisplatin by Targeting the miR-155-5p/PDK1 Axis[J]. Mol Ther Nucleic Acids, 2021, 23: 244-254. doi: 10.1016/j.omtn.2020.08.037
|
| [37] |
Xin X, Lu Y, Xie S, et al. miR-155 Accelerates the Growth of Human Liver Cancer Cells by Activating CDK2 via Targeting H3F3A[J]. Mol Ther Oncolytics, 2020, 17: 471-483. doi: 10.1016/j.omto.2020.05.002
|
| [38] |
Yin Y, Yao S, Hu Y, et al. The Immune-microenvironment Confers Chemoresistance of Colorectal Cancer through Macrophage-Derived IL6[J]. Clin Cancer Res, 2017, 23(23): 7375-7387. doi: 10.1158/1078-0432.CCR-17-1283
|
| [39] |
Wu L, Jiang F, Shen X. Helicobacter pylori CagA Protein Regulating the Biological Characteristics of Gastric Cancer through the miR-155-5p/SMAD2/SP1 axis[J]. Pathogens, 2022, 11(8): 846. doi: 10.3390/pathogens11080846
|
| [40] |
Huang J, Weng Q, Shi Y, et al. MicroRNA-155-5p suppresses PD-L1 expression in lung adenocarcinoma[J]. FEBS Open Bio, 2020, 10(6): 1065-1071. doi: 10.1002/2211-5463.12853
|
| [41] |
Xia R, Geng G, Yu X, et al. LINC01140 promotes the progression and tumor immune escape in lung cancer by sponging multiple microRNAs[J]. J Immunother Cancer, 2021, 9(8): e002746. doi: 10.1136/jitc-2021-002746
|
| [42] |
Li Y, Zhang L, Dong Z, et al. MicroRNA-155-5p promotes tumor progression and contributes to paclitaxel resistance via TP53INP1 in human breast cancer[J]. Pathol Res Pract, 2021, 220: 153405. doi: 10.1016/j.prp.2021.153405
|
| [43] |
Gu W, Gong L, Wu X, et al. Hypoxic TAM-derived exosomal miR-155-5p promotes RCC progression through HuR-dependent IGF1R/AKT/PI3K pathway[J]. Cell Death Discov, 2021, 7(1): 147. doi: 10.1038/s41420-021-00525-w
|
| [44] |
Karabon L, Andrzejczak A, Ciszak L, et al. BTLA Expression in CLL: Epigenetic Regulation and Impact on CLL B Cell Proliferation and Ability to IL-4 Production[J]. Cells, 2021, 10(11): 3009. doi: 10.3390/cells10113009
|
| [45] |
Li X, Wang S, Mu W, et al. Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway[J]. J Exp Clin Cancer Res, 2022, 41(1): 41. doi: 10.1186/s13046-022-02244-1
|
| [46] |
Li N, Cui T, Guo W, et al. MiR-155-5p accelerates the metastasis of cervical cancer cell via targeting TP53INP1[J]. Onco Targets Ther, 2019, 12: 3181-3196. doi: 10.2147/OTT.S193097
|
| [47] |
Ning M, Qin S, Tian J, et al. LncRNA AFAP-AS1 promotes anaplastic thyroid cancer progression by sponging miR-155-5p through ETS1/ERK pathway[J]. Bioengineered, 2021, 12(1): 1543-1554. doi: 10.1080/21655979.2021.1918537
|
| [48] |
Geng X, Sun YY, Fu JJ, et al. Role of miR-155-5p expression and its involvement in apoptosis-related factors in thyroid follicular carcinoma[J]. J Clin Pharm Ther, 2020, 45(4): 660-665. doi: 10.1111/jcpt.13175
|
| [49] |
Gao Y, Xu J, Li H, et al. Identification of Metastasis-Associated MicroRNAs in Metastatic Melanoma by miRNA Expression Profile and Experimental Validation[J]. Front Genet, 2021, 12: 663110. doi: 10.3389/fgene.2021.663110
|
| [50] |
Wang S, Gao Y. Pancreatic cancer cell-derived microRNA-155-5p-containing extracellular vesicles promote immune evasion by triggering EHF-dependent activation of Akt/NF-kappaB signaling pathway[J]. Int Immunopharmacol, 2021, 100: 107990. doi: 10.1016/j.intimp.2021.107990
|
| [51] |
Luo X, Dong J, He X, et al. MiR-155-5p exerts tumor-suppressing functions in Wilms tumor by targeting IGF2 via the PI3K signaling pathway[J]. Biomed Pharmacother, 2020, 125: 109880. doi: 10.1016/j.biopha.2020.109880
|
| [52] |
Bao Z, Zhang N, Niu W, et al. Exosomal miR-155-5p derived from glioma stem-like cells promotes mesenchymal transition via targeting ACOT12[J]. Cell Death Dis, 2022, 13(8): 725. doi: 10.1038/s41419-022-05097-w
|
| [53] |
Wang D, Xiong F, Wu G, et al. MiR-155-5p suppresses SOX1 to promote proliferation of cholangiocarcinoma via RAF/MEK/ERK pathway[J]. Cancer Cell Int, 2021, 21(1): 656. doi: 10.1186/s12935-021-02374-0
|
| [54] |
Yang Y, Zhang G, Li J, et al. Long noncoding RNA NORAD acts as a ceRNA mediates gemcitabine resistance in bladder cancer by sponging miR-155-5p to regulate WEE1 expression[J]. Pathol Res Pract, 2021, 228: 153676. doi: 10.1016/j.prp.2021.153676
|
| [55] |
郑春娇, 吴智明, 王彦双, 等. lncRNA-CASC2/miR-155-5p/APC分子轴调控非霍奇金淋巴瘤发展进程的分子机制[J]. 中国实验血液学杂志, 2020, 28(6): 1939-1945. doi: 10.19746/j.cnki.issn1009-2137.2020.06.024
Zheng CJ, Wu ZM, Wang YS, et al. The Molecular Mechanism of LncRNA-CASC2/miR-155-5p/APC Axis Regulating the Progression of Non-Hodgkin Lymphoma[J]. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2020, 28(6): 1939-1945. doi: 10.19746/j.cnki.issn1009-2137.2020.06.024
|
| [1] | GUO Xin, DU Hua, SHI Yingxu. Exosomal Delivery of Non-coding RNA Regulates Breast Bancer Drug Resistance[J]. Cancer Research on Prevention and Treatment, 2022, 49(10): 1071-1076. DOI: 10.3971/j.issn.1000-8578.2022.22.0142 |
| [2] | WANG Lin, HUANG Zixian, YOU Chengcheng, TAN Shunzi, HUANG Liming, HUANG Yiling. Screening of Molecular Markers of Cisplatin Resistance in Lung Adenocarcinoma and Functional Verification Based on TCGA Database[J]. Cancer Research on Prevention and Treatment, 2022, 49(6): 569-574. DOI: 10.3971/j.issn.1000-8578.2022.21.1181 |
| [3] | SONG Wenjing, LIU Shuting, HE Xin, GONG Pengju, YANG Yan, WEI Lei, ZHANG Jingwei. Expression Level of VSIG4 in Breast Cancer and Its Correlation with Immune Infiltration and Prognosis[J]. Cancer Research on Prevention and Treatment, 2021, 48(5): 489-496. DOI: 10.3971/j.issn.1000-8578.2021.20.1026 |
| [4] | KE Chunjin, HU Zhiquan, YUE Daoyuan, SHEN Yuanqing, GAN Jiahua, TIAN Jihua, LI Song, LI Le, YANG Chunguang. Application of Tumor Markers in Patients with Urachal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2020, 47(9): 676-679. DOI: 10.3971/j.issn.1000-8578.2020.20.0161 |
| [5] | YU Xuedi, SHE Chunhua, SUN Zengfeng, LIU Jingjing, MA Li, LI Wenliang. Predictive Value of Preoperative Hematologic Inflammatory Markers in Prognostic of Glioma Patients[J]. Cancer Research on Prevention and Treatment, 2019, 46(8): 714-719. DOI: 10.3971/j.issn.1000-8578.2019.19.0163 |
| [6] | LI Shaolei, MA Yuanyuan, XIONG Ying, ZHANG Shanyuan, HUANG Miao, YANG Yue. Role of Serum Tumor Markers in Prognosis of Operable Non-small Cell Lung Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2018, 45(1): 24-28. DOI: 10.3971/j.issn.1000-8578.2018.17.0854 |
| [7] | HUANG Xuan, ZHANG Xun. Advance of Prognostic Markers of Cervical Cancer[J]. Cancer Research on Prevention and Treatment, 2016, 43(9): 806-810. DOI: 10.3971/j.issn.1000-8578.2016.09.016 |
| [8] | YAN Xinxing, WANG Jing, ZHANG Wei, KE Xiaoyan. Expression of Toll-like Receptor 4 in Lymphoma Cell Lines and Its Effect on Cells Proliferation and Drug Resistance[J]. Cancer Research on Prevention and Treatment, 2016, 43(6): 437-441. DOI: 10.3971/j.issn.1000-8578.2016.06.001 |
| [9] | FAN Guo-yu, WU Xiao-kui, LI Chun-guo. Diagnosis Value of Tumor Markers for Malignant Pleural Effusions[J]. Cancer Research on Prevention and Treatment, 2011, 38(04): 434-436. DOI: 10.3971/j.issn.1000-8578.2011.04.018 |
| [10] | LU Hong, FAN Qing-xia, WANG Rui-lin. Apoptosis in Paclitaxel Resistant Cell Line Ec9706/P-1 of Human Esophageal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2010, 37(12): 1356-1359. DOI: 10.3971/j.issn.1000-8578.2010.12.006 |
| 1. |
周慧芳，康敏荣，戴雪娥，闫廷玺，王晓彤，闫伟. miR-340-5p、miR-155-5p在慢性乙型肝炎患者中的表达及与Th1/Th2细胞因子水平的关系. 国际检验医学杂志. 2025(02): 205-209 .
| |
| 2. |
刘杰，姚磊，陈雅婷，王雪玉，王坤，韩卫卫，槐月霞，赵阳. miR-155-5p调控甲状腺癌细胞增殖凋亡机制. 生物技术. 2025(02): 187-192 .
| |
| 3. |
严学倩，刘利，及月茹，秦炜炜，肖方，陈怡. 血清miR-155-5p和miR-146b-5p与继发性急性髓系白血病染色体畸变及预后的关系. 武警医学. 2024(01): 14-20+24 .
| |
| 4. |
余祖华，高梦茹，何雷，魏颖，陈建，陈松彪，丁轲. mdv1-miR-M4-5p对MDCC-MSB1细胞增殖和凋亡的影响. 畜牧兽医学报. 2024(08): 3678-3687 .
| |
| 5. |
叶汉挹，吕舜，黎迎，董政起. 植物来源miR261、miR354及miR194调控多种肿瘤细胞增殖并靶向HDAC2或CTLA-4. 生命科学研究. 2024(06): 483-492 .
|
Tables(1)
This work is licensed under a Creative Commons Attribution 3.0 License.
Copyright © Editorial Department of Cancer Prevention Research 鄂公网安备 42011102005013号 鄂ICP备2022015867号
Supported by: Beijing Renhe Information Technology Co., Ltd. 
DownLoad: