Prognostic Model Based on Preoperative FAR and SII Versus TNM Staging System in Evaluating Prognosis of Patients with Pancreatic Cancer After Radical Resection

LIU Xudong; ZHAO Bin; DU Peng; ZHANG Guoqiang; ZHENG Qiang; LAI Jiamin; CHENG Zhibin

doi:10.3971/j.issn.1000-8578.2023.22.1090

Cancer Research on Prevention and Treatment > 2023 > 50(3): 264-270. > DOI: 10.3971/j.issn.1000-8578.2023.22.1090

LIU Xudong, ZHAO Bin, DU Peng, ZHANG Guoqiang, ZHENG Qiang, LAI Jiamin, CHENG Zhibin. Prognostic Model Based on Preoperative FAR and SII Versus TNM Staging System in Evaluating Prognosis of Patients with Pancreatic Cancer After Radical Resection[J]. Cancer Research on Prevention and Treatment, 2023, 50(3): 264-270. DOI: 10.3971/j.issn.1000-8578.2023.22.1090

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Prognostic Model Based on Preoperative FAR and SII Versus TNM Staging System in Evaluating Prognosis of Patients with Pancreatic Cancer After Radical Resection

Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730000, China

Funding:

National Natural Science Foundation of China 82060508

Gansu Health Industry Scientific Research Program GSWSKY-2019-66

Gansu Higher Education Innovation Fund Project CY2020-MS04

More Information

Corresponding author:
CHENG Zhibin,E-mail: zhibin_cheng@hotmail.com
Received Date: September 18, 2022
Revised Date: November 21, 2022
Available Online: January 12, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the predictive value of preoperative fibrinogen/albumin ratio (FAR) and systemic immune inflammation index (SII) on the postoperative prognosis of patients with pancreatic ductal adenocarcinoma.
Methods
An ROC curve was used in determining the best cutoff values of FAR and SII and then grouped. The Cox proportional hazards model was used in analyzing the prognostic factors of radical pancreatic cancer surgery, and then a Nomogram prognostic model was established. C-index, AUC, and calibration curve were used in evaluating the discrimination and calibration ability of the Nomogram. DCA curves were used in assessing the clinical validity of the Nomograms.
Results
The optimal cutoff values for preoperative FAR and SII were 0.095 and 532.945, respectively. FAR≥ 0.095, SII≥ 532.945, CA199≥ 450.9 U/ml, maximum tumor diameter≥ 4 cm, and the absence of postoperative chemotherapy were independent risk factors for the poor prognosis of pancreatic cancer (P<0.05). The discrimination ability, calibration ability, and clinical effectiveness of Nomogram prognostic model were better than those of the TNM staging system.
Conclusion
The constructed Nomogram prognostic model has higher accuracy and level of discrimination and more clinical benefits than the TNM staging prognostic model.
- Pancreatic ductal adenocarcinoma,
- Fibrinogen/albumin ratio,
- Systemic immune inflammation index,
- Nomogram,
- Prognostic model

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Competing interests: The authors declare that they have no competing interests.

References (36)

References

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Prognostic Model Based on Preoperative FAR and SII Versus TNM Staging System in Evaluating Prognosis of Patients with Pancreatic Cancer After Radical Resection