Research Progress on Anti-Tumor Mechanism of Theaflavins Natural Products

ZHANG Xue; YIN Junli; WANG Jiaxiang; SHI Wengui; JIAO Zuoyi

doi:10.3971/j.issn.1000-8578.2022.21.1292

Cancer Research on Prevention and Treatment > 2022 > 49(8): 820-826. > DOI: 10.3971/j.issn.1000-8578.2022.21.1292

ZHANG Xue, YIN Junli, WANG Jiaxiang, SHI Wengui, JIAO Zuoyi. Research Progress on Anti-Tumor Mechanism of Theaflavins Natural Products[J]. Cancer Research on Prevention and Treatment, 2022, 49(8): 820-826. DOI: 10.3971/j.issn.1000-8578.2022.21.1292

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Research Progress on Anti-Tumor Mechanism of Theaflavins Natural Products

1.
Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou 730030, China
2.
Cuiying Biomedical Research Center, Second Hospital of Lanzhou University, Lanzhou 730030, China

Funding:

National Natural Science Foundation of China 82160487

Cuiying Student Research and Cultivation Project of the Second Hospital of Lanzhou University CYXZ2020-37

More Information

Corresponding author:
JIAO Zuoyi, E-mail: jiaozy@lzu.edu.cn
Received Date: November 08, 2021
Revised Date: February 22, 2022
Available Online: January 12, 2024

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Abstract

Abstract

Theaflavins are a class of natural products extracted from black tea or green tea, with significant anti-tumor effects on gastric cancer, liver cancer, breast cancer and other tumors. Theaflavins were once considered as the new products for anticancer therapy. However, the anti-tumor mechanism of theaflavins involves a variety of biological processes, and the regulation is complex. Therefore, this article summarizes the role of theaflavins in promoting tumor cell apoptosis, inducing tumor cell mitotic arrest and regulating tumor immunity, and reviews the inhibition of tumorigenesis and growth through MAPK, PI3K/AKT, Hedgehog, NF-κB, JAK/STAT and Wnt/β-Catenin signal pathways, in order to provide new ideas for cancer treatment and anti-cancer drug development.
- Theaflavins,
- Signal path,
- Anticancer,
- Mechanism

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Competing interests: The authors declare that they have no competing interests.

References (50)

References

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Research Progress on Anti-Tumor Mechanism of Theaflavins Natural Products